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Published byHomer Chandler Modified over 9 years ago
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Cell Junctions, Cell Adhesion, and the Extracellular Matrix
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The role of tight junction
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Anchoring junction
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Adherens junction
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Desmosomes
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Focal adhesions
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Desmosomes and Hemidesmosomes
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Gap junction channel
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Gap junctions
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Gap junction coupling in the ovarian follicle
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The regulation of gap-junction coupling by a neurotransmitter
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Cell-Cell Adhesion Three mechanisms of cell-cell adhesion
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The structure and function of cadherins
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Cadherin-dependent cell sorting
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Cadherin diversity in the CNS
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The linkage of classical cadherins to actin filaments
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The structure and function of selectins
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The cell adhesion protein N-CAM
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The connective tissue underlying an epithelium
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The repeating disaccharide sequence of a dermatan sulfate glycosaminoglycan (GAG) chain
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The relative dimensions and volumes occupied by various macromolicules
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The repeating disaccharide sequence in hyaluronan
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The linkage between a GAG chain and its core protein in proteoglycan molecule
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Examples of proteoglycan
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An aggrecan
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Structure of a typical collagen molecule
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Type IX collagen
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Stretching a network of elastin molecules
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The structure of fibronectin dimer
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The structure of laminin
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Three ways in which basal laminae are organized
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The molecular structure of a basal lamina
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The comparative shapes and sizes of some of the major ECM macromolecules
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The ECM can influence cell shape, cell survival, and cell proliferation
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Anchorage dependence and the importance of cell spreading
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The degradation of matrix components Slow and continuous turnover of ECM Matrix metalloproteases Serine protease Controlled, specific degradation -> important to cell migration *Clear a path through matrix *Expose cryptic sites that promote cell binding, cell migration *Promote cell detachment *Release signal proteins that stimulate cell migration Tightly controlled Local activation; plasminogen activator activates inactive plasminogen to plasmin Confinement by cell-surface receptor; urokinase-type plasminogen activator Secretion of inhibitor; tissue inhibitors of metalloproteases, serpins
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The importance of proteases bound to cell-surface receptors
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The structure of an integrin receptor
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The regulation of the extracellular binding activity of a cell’s integrins from within
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Excessive numbers of focal adhesions in FAK-deficient fibroblasts
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Matrix-dependent cell survival in the formation of the proamniotic cavity
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