1. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors

2. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors

3. History of interaction Start session Enter knowledge Enter Knowledge Describe in English the knowledge to be entered Search for knowledge already in the system Go back to start

4. Enter Knowledge Describe in English the knowledge to be entered Search for knowledge already in the system History of interaction Start session Enter knowledge Go back to start

5. Enter Knowledge Describe in English the knowledge to be entered: I will describe ``how a virus infects a cell.’’ History of interaction Go back to start Start session Enter knowledge Describe in English the knowledge to be entered

6. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

7. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

8. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start composing Go back to start Summary of retrieved information Infectious agents whose genomes are composed of DNA or RNA, but not both. They lack independent metabolism and ability to replicate outside living host cells. History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

9. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Infectious agents whose genomes are composed of DNA or RNA, but not both. They lack independent metabolism and ability to replicate outside living host cells.

10. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Infectious agents whose genomes are composed of DNA or RNA, but not both. They lack independent metabolism and ability to replicate outside living host cells.

11. Summary of retrieved information Infectious agents whose genomes are composed of DNA or RNA, but not both. They lack independent metabolism and ability to replicate outside living host cells. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms. History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

12. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

13. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

14. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell The system does not recognize the following concepts. Click on each to identify closely matching concept. 1. Infect Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

15. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms. Search for a Concept Search by concept name Viewpoint search Concept map search English query Look for similar concepts Go back to start Form-oriented search Search by drawing a concept map Search by queries in English Search based on NL metaphors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

16. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Search for a Concept Search by concept name Viewpoint search Concept map search English query Look for similar concepts Go back to start Form-oriented search Search by drawing a concept map Search by queries in English Search based on NL metaphors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

17. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Is infect a 1.Motion process 2. Forceful interaction 3. Object manipulation History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

18. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Is infect 1. Motion process 2. Forceful interaction 3. Object manipulation History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

19. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Is infect like a forceful interaction such as Basic force pattern Conflict Competition Cooperation History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms. E.g., let, hinder, etc.

20. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Is infect like a forceful interaction such as Basic force pattern Conflict Competition Cooperation History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

21. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Select the conflict most closely matching to Infect Invade …... History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

22. Search for a Concept Go back to start Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Select the conflict most closely matching to Infect Invade …... History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Summary of retrieved information Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms.

23. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Summary of retrieved information A cell is a kind of a container which contains cytoplasm. Summary of retrieved information An invade is a process in which the invader wants to take control of the object being invaded. It has subevents: enter, penetrate, and take control. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell 3. Infect closely matches to Invade Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

24. Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Summary of retrieved information A cell is a kind of a container which contains cytoplasm. Summary of retrieved information An invade is a process in which the invader wants to take control of the object being invaded. It has subevents: enter, penetrate, and take control. Enter Knowledge In ``how a virus infects a cell’’, the system recognizes the following concepts. Please click on each of them in turn to insure that they have intended meanings. 1. Virus 2. Cell 3. Infect closely matches to Invade Start Composing Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts

25. History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS Summary of retrieved information A virus is a kind of a container. Its structural parts are DNA and a protein coat. Summary of retrieved information A cell is a kind of a container which contains cytoplasm. Summary of retrieved information An invade is a process in which the invader wants to take control of the object being invaded. It has subevents: enter, penetrate, and take control. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell PenetrateEnter TakeControl ????? subevents patientagent Invade Concept Map window has an independent thread of control. The user can do all the editing in this window, and when done, can resume the dialog. The user can also start a new interaction. CellVirus Summary windows can be dismissed at user’s discretion

26. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell PenetrateEnter TakeControl ????? subevents InvadeeInvader Invade VirusCell History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS Drag and drop over question marks

27. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS

28. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Do a put map from concept maps History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS

29. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved

30. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Test Knowledge Select the concept to be tested VirusInfectsCell Virus Cell Invade Search for a new concept History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge

31. Test Knowledge VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Select the concept to be tested VirusInfectsCell Virus Cell Invade Search for a new concept History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge

32. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell The Penetrate action requires that the Virus should be near the Cell. This action cannot be performed. I propose the following fixes. 1. Assume that the Virus is close to the Cell before start of VirusInfectsCell 2. Add another step in VirusInfectsCell that brings the Virus near the cell. Possible step: Arrive Go back to start

33. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell The Penetrate action requires that the Virus should be near the Cell. This action cannot be performed. I propose the following fixes. 1. Assume that the Virus is close to the Cell before start of VirusInfectsCell 2. Add another step in VirusInfectsCell that brings the Virus near the cell. Go back to start

34. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Choose a step to be added: 1. Arrive 2. Move 3. Search for another step Go back to start Fix Errors

35. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Choose a step to be added: 1. Arrive 2. Move 3. Search for another step Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors

36. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Choose a step to be added: 1. Arrive 2. Move 3. Search for another step Go back to start Arrive ??? agent destination History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors

37. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Arrive agent patient Dialog Window Test VirusInfectsCell again Ask a question Enter knowledge Test knowledge Fix errors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors

38. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Arrive agent patient Dialog Window Test VirusInfectsCell again Ask a question Enter knowledge Test knowledge Fix errors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors

39. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeetInvader Invade Arrive agent patient Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Summary of knowledge testing After VirusInfectsCell, the virus is inside the cell. The virus first arrives near the cell, then penetrates the cell, then enters it, and then takes control of the cell.

40. Dialog Window VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Ask a question Enter knowledge Test knowledge Fix errors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge

41. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Enter Knowledge Add more knowledge about VirusInfectsCell Enter knowledge about a different topic Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge

42. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Enter Knowledge Add more knowledge about VirusInfectsCell Enter knowledge about a different topic Go back to start Since the user is continuing with the same concept, the dialog will maintain correspondence to the existing Concept Map Window History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell

43. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvadert Invade Enter Knowledge Go back to start Describe in English the knowledge to be entered Import a concept for composition History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell

44. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Enter Knowledge Go back to start Describe in English the knowledge to be entered Import a concept for composition History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition

45. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Search a concept Search by concept name Viewpoint search Concept map search English query Look for similar concepts Go back to start Form-oriented search Search by drawing a concept map Search by queries in English Search based on NL metaphors History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition

46. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Search a Concept Search by concept name Viewpoint search Concept map search English query Look for similar concepts Go back to start History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition Search by concept name

47. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Search Concept Search for concept: History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition Search by concept name

48. VirusInfectsCell PenetrateEnter TakeControl Virus Cell subevents InvadeeInvader Invade Search Concept Search for concept: Endocytosis History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition Search by concept name

49. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Summary of retrieved information Endocytosis is cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. Endocytosis subevents Pinchoff Enter VirusCell patientagent History of interaction Start session Enter knowledge Describe in English the knowledge to be entered Identify pre-existing concepts Enter knowledge Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Fix Errors Test VirusInfectsCell Enter knowledge Enter more knowledge about VirusInfectsCell Import a concept for composition Search by concept name Compose using CMAPS

50. History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter VirusCell patientagent ??? Ask for options through the CMAP Interface

51. History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter VirusCell patientagent ??? Choose an arc: subevents byMeans of ….

52. History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter VirusCell agent ??? Choose an arc: subevents byMeans of ….

53. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter VirusCell Patientagent byMeansOf History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS

54. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

55. VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Dialog Window Ask a question Enter knowledge Test knowledge Fix errors Put Map through CMAP interface

56. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

57. Test Knowledge Select the concept to be tested Endocytosis VirusInfectsCell Virus Cell Invade Search for a new concept Go back to start History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

58. Test Knowledge Select the concept to be tested Endocytosis VirusInfectsCell Virus Cell Invade Search for a new concept Go back to start History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

59. Test Knowledge Select the concept to be tested Endocytosis VirusInfectsCell Virus Cell Invade Search for a new concept Go back to start Testing of VirusInfectsCell Assuming that virus is near the Cell, after VirusInfectsCell, the virus is inside the cell. Virus Penetrates the Cell by means of Endocytosis, which is process performed by a Cell on the Virus, and then enters the cytoplasm of the cell. History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Summary of knowledge testing VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

60. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell

61. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

62. Search for Concept What concept do you want to ask a question about? VirusInfectsCell Virus Cell Endocytosis Pinchoff Some other concept History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

63. Search for Concept What concept do you want to ask a question about? VirusInfectsCell Virus Cell Endocytosis Pinchoff Some other concept History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf

64. VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf Concept: VirusInfectsCell Questions: Describe how a virus invades a cell Under what conditions can a virus invade a cell? What role does the membrane play when a virus invades a cell? What is the effect of increasing temperature when a virus invades a cell? How is membrane penetration achieved when a virus invades a cell? Partially instantiated question templates. Boxed words denote pull-down menus for varying the question. Hyperlinks to online text Question AskingHistory of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question Ask question about VirusInfectsCell

65. VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf Concept: VirusInfectsCell Questions: Describe how a virus invades a cell Under what conditions can a virus invade a cell? What role does the membrane play when a virus invades a cell? What is the effect of increasing temperature when a virus invades a cell? How is membrane penetration achieved when a virus invades a cell? Question Asking History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question Ask question about VirusInfectsCell

66. Summary of retrieved information Describe how a virus invades a cell During virus invades cell, the following subevents occur: * First, the virus penetrates the cell (more details) * Then, the virus enters the cell (more details) * Finally, the virus takes control of the cell (more details) Machine-synthesized answer. “more details” allows the user to “drill down” into details of how a particular step occurs. Machine-synthesized answer. “more details” allows the user to “drill down” into details of how a particular step occurs. VirusInfectsCell Penetrate Invaginate TakeControl subevents InvadeeInvader Invade Cell Virus Endocytosis subevents Pinchoff Enter patientagent byMeansOf Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question Ask question about VirusInfectsCell

67. Dialog Window Ask a question Enter knowledge Test knowledge Fix errors History of interaction Add more knowledge about VirusInfectsCell Test knowledge Test VirusInfectsCell Enter Knowledge Import a concept for composition Search by concept name Compose using CMAPS VirusInfectsCell saved Test knowledge Test VirusInfectsCell Ask question Ask question about VirusInfectsCell

68. Next Steps Add analogy –Add Ken’s analogy interface Should we include old-fashioned ontology editing? Get it reviewed from SMEs How to represent effects of actions