1. Animals in Research Donald B. Casebolt Director, Department of Animal Resources

2. Objectives  Responsibilities of the institution  Responsibilities of the principal investigator

3. “The development of knowledge necessary for the improvement of the health and well-being of humans as well as other animals requires in vivo experimentation with a wide variety of animal species.” (United States Office of Science and Technology Policy, 1985)

4. Federal Laws  Animal Welfare Act US Department of Agriculture  Health Research Extension Act National Institutes of Health Office of Laboratory Animal Welfare

5. Similarities of Two Laws  Institutional Official  Institutional Animal Care and Use Committee  Program of veterinary care  Training of personnel “Enforced Self-Regulation”

6. AAALAC Accreditation

7. IACUC Membership  Scientist  Veterinarian with training and/or experience in laboratory animal medicine  Nonscientist  At least one member not affiliated with the institution (public member)

8. IACUC Responsibilities  Review the programs of animal care and use  Inspect animal facilities and procedure areas  Approve, require modifications prior to approval, or withhold approval of animal use protocols  Approve any changes to animal use protocols  The IACUC is authorized to suspend a protocol

9. Principal Investigator Responsibilities  Preparation and submission of Animal Use Protocols  Modifications to protocols  Justification of animal species and numbers  Training of personnel in appropriate methods  Occupational health and safety of personnel  Avoidance of animal pain and distress  Development of humane endpoints  Animal euthanasia methods

10. iStar for IACUC

14. Training  Species-specific  Protocol-specific  Web based and hands-on

15. Questions?