2. Hormone: Thyroxin Overactivity (Too much hormone) - Increased metabolic rate - Increased food intake but loss of weight - Hyperthyroidism (Grave’s disease) - Goitre (swollen neck, maybe bulging eyes)

3. Grave’s disease

4. Hormone: Thyroxin Underactivity (Not enough hormone) - Hypothyroidism (Hashimoto’s disease) - Reduced metabolic rate - Low food intake but gain of weight - Myxoedema (when onset in adults) - Cretinism- stunted mental and physical growth (in children) - Can also cause a goitre

5.  Puffiness (swelling)  Fatigue  Obesity  Dry, thickened skin  Mental impairment  Thin, brittle hair

6.  Protuberant abdomen  Short Stature  Infertility  Neurological impairment  Constant Fatigue  Obesity

7. Hormone: Calcitonin Overactivity - Increased Bone Ca, decreased Blood Ca - Tetany (nerve problems leading to muscle spasms or cramps) Underactivity - Increase Blood Ca, decreased Bone Ca - Osteoporosis (brittle bones) - Kidney stones

8. Hormone: Parathormone (PTH) Underactivity - Low Blood calcium, High Bone Ca - Tetany Overactivity - High Blood calcium, Low Bone Ca - Osteoporosis

9. Hormone: Insulin Overactivity - Low blood sugar level ( ↓BSL) - Hypoglycemia Underactivity - High blood sugar level ( ↑BSL) - Hyperglycemia - Diabetes

10. Hormone: Glucagon Overactivity - High blood sugar level ( ↑BSL) - Diabetes Underactivity - Low blood sugar level ( ↓BSL) - Hyper insulinism

11. Hormone: Growth Hormone Overactive - Giantism (children - very tall) - Acromegaly (adults - bones & skin thicken) Underactive - Dwarfism (very short)

12. The man holding the baby in the photo is 8 ft, 2.5 inches tall

14. Dwarfism occurs when there is short supply of GH in childhood. There are two types of dwarfism – Lorrain and Frohlich’s

15. Overactive  Goitre  Hyperthyroidism  Grave’s Disease Underactive  Goitre  Hypothyroidism  Hashimoto’s Disease  Myxoedema (adults)  Cretinism (kids)

16. Overactive  Tetany Underactive  Kidney Stones  Osteoporosis

17. Overactive  Kidney Stones  Osteoporosis Underactive  Tetany

18. Overactive  Hypoglycemia  Hyperinsulinism (insulin shock) Underactive  Hyperglycemia  Diabetes

19. Calcitonin –Parathormone - Over Reactivity Under Reactivity Blood Ca Tetany Osteoporosis Kidney Stones Osteoporosis Kidney Stones Blood Ca

20. Overactive  Hyperglycemia  Diabetes Underactive  Hypoglycemia  Hyperinsulinism

21. Insulin –Glucagon - Over Reactivity Under Reactivity BSL Hyperglycemia Diabetes BSL Hyperglycemia Diabetes Hypoglycemia BSL Hypoglycemia BSL

22. Overactive  Giantism (children)  Acromegaly (adults) Underactive  Dwarfism (Frohlich’s and Lorrain)

23. Overactive  Skin darkens Under active  Skin will not darken  Most severe condition is albinism

24. Overactive  Unknown Underactive  Sterility

25. Overactive  Cushing’s Syndrome Underactive  Addison’s Disease  Decreased cortisol and/or aldosterone production