1. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Transport of Oxygen and Carbon Dioxide Lesson Objective : To describe and explain how oxygen and carbon dioxide are carried in blood and the effect of exercise

2. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Blood Composition What is in blood? –55% Plasma –45% Red Blood Cells (Erythrocytes) –<1% White Blood Cells (Leukocytes) & Platelets

3. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Oxygen Transport In Solution… 0.3ml per 100ml –Not very soluble Average blood volume = 5 litres –15ml of oxygen –4 seconds –Or 80 litres/minute at rest Physiologically important with Haemoglobin… Protein containing iron Sup up Oxygen carrying capacity –60-70 times –197ml/litre KEY POINT O 2 transported in 2 ways 1.3% In solution 2.97% with haemoglobin

4. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Haemoglobin Has 4 Iron molecules that can attract 4 oxygen molecules Hb 4 + 4O 2  Hb 4 O 8 Oxyhaemoglobin Depends on partial pressure of oxygen

5. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Carbon Dioxide Transport In solution… 5% Physiologically important With water… 70% Carbonic Acid Slow process Carbonic Anhydrase speeds up x 5000 With haemoglobin… 25% Carboaminohaemoglobin Partial Pressure of O 2 Partial Pressure of CO 2 CO 2 transported in 3 ways

6. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Oxygen-Haemoglobin Dissociation Curve! Blood Oxygen Capacity = Hb (g) x O 2 in Hb 15g of Hb / 100ml 1.34ml of oxygen / Hb g Answer is… 20ml of oxygen per 100ml of blood when breathing ambient air at sea level

7. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise Your Mission Haemoglobin is not always saturated or associated with oxygen 1.Look at the ‘x’ axis on the following graph what does it show? 2.Draw a line up from 100 the axis to intersect the curve and then across to the ‘y’ axis. What is the % Saturation? 3.Do the same from 40. What is the % Saturation?

8. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise You should have this…

9. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise

10. The Bohr-ing Effect of Exercise To get more oxygen dissociation we need the graph to move down and right 1.Increase in blood & muscle temperature 2.Decrease in PPO 2 within muscle 3.Increase in PPCO 2 within muscle 4.Increase in acidity THE BOHR EFFECT

11. To describe and explain how O 2 and CO 2 are carried in blood and the effect of exercise

12. Pupil Tasksheet