1. Translation and Innovation Mark Chance, PhD Vice Dean for Research School of Medicine October 19, 2015

2. Translation and Innovation at CWRU School of Medicine Leading the Way School of Medicine boasts a vibrant pipeline of highly innovative translational programs – Expert guidance is provided through chief translational officers and the Technology Transfer Office Disciplined vetting processes in place to select high potential programs to invest in Council to Advance Human Health (CAHH) promotes translation by funding key proof of concept studies focused on preclinical development of drugs

3. Discovery Preclinical Development Lead Optimization Taiwan Medical U./CTSC Fund CAHH Innovation Fund TTO Innovation Fund CTSC and CCCC Pilot Grants Harrington Scholar NCAI Grants Coulter Translation Program NIH funding HTS Pilots Ohio Third Frontier NIH SBIR/STTR ONE Fund CTO Road Show BioMotiv New Company Private Investment License Industry Partner Preclinical Optimization HTS = high throughput screening CAHH = Council to Advance Human Health NCAI = National Centers for Accelerated Innovations CTUHV = Case Technologies and University Hospitals Venture Fund CTO = Chief Translational Officers Medical Innovation Pipeline

4. Hundreds of SOM research programs 50 15 3 Vetting Technologies: CAHH Investigators meet with our experts regularly Programs marketed to major pharma and biotech annually Programs presented to CAHH annually (11 funded since 2012) More than 70 eligible inventions at various stages

5. 26 Case Coulter Translational Funding Pipeline Letters of Intent received (2012-2015) - 1 round annually Full proposals submitted Funded proposals ($100K each) Presentations to review committee 115 72 44

6. 212 51 12 National Center for Accelerated Innovation Translational Funding Pipeline TotalsCWRU/UHCMC 57 19 4 Letters of Intent received (2-3 rounds/yr) Full proposals submitted Funded proposals ($100K-$125K each)* *first 3 rounds, 4 th round pending

7. TranslationMarketing Totaling over $10M in new investments Commercialization Program: Culture and Product New funding New companies Culture change Industry licenses

8. Proposed for-profit fund outside the university Interested in early look at vetted discoveries across the University Opportunities for New Exits: ONE Fund The ONE Fund will provide critical funding needed to develop CWRU opportunities

9. Translational Research Program Collaboration CAHH NCAI GLEI COULTER Weatherhead Diligence Engines Review and Analysis Modest funding or in-kind support Peer review Mentorship and advice

10. FundingPrograms Product Value Creation $300M/year $2M/year $6M/year +100 10-15 2-3 non-profit for profit

11. Thank you.