1. Life Sciences Luxembourg Centre for Systems Biomedicine
UL evaluation 2012
Life Sciences Luxembourg Centre for Systems Biomedicine
(LCSB)
17th February 2012
4/25/2017

2. LCSB: An Interdisciplinary Centre within the University
Language
Literature
Humanitites
Arts
Education
(FLSHASE)
Systems Biomedicine
(LCSB)
Science
Technology
Communication
(FSTC)
Law
Economics
Finance
(FDET)
Security, Reliability, Trust
(SNT)
Faculties
Interdisciplinary
Centres

3. LCSB: The First 2 Years
September 2009
September 2011

4. Luxembourg Centre for Systems Biomedicine (LCSB)
Experimental
Biology
Computational
Biology
LCSB
Technical
Platforms
Clinical
Research

5. The interdisciplinary nature of the LCSB
Technology
Theory
Transcriptomics
Proteomics
Metabolomics
Bioinformatics
Computational Biology
Modelling and Simulation
Animal Models Human Genetics
Public
Health
Parkinson`s Disease
Chemical Biology
Imaging
Experimental Biomedicine
Gene-Environment Interactions
Experiments
4/25/2017

6. Network models of diseases: Inference and analysis
Thematic focus
Computer
Cells
Mice
Patients
Families
Network models of diseases: Inference and analysis

7. Thematic focus Parkinson´s Disease Genetics & Genomics
Mol.- & Cellular Biology
Computational Biology
Clinical Translation

8. Thematic focus The LCSB Parkinson's Disease Research Program
Nico Diederich
Paul Antony
Mitochondrial dysfunction
in PD patients
Metabolome analysis
of PD-patients
Clinical PD projects
Karsten Hiller
Sequencing of PD patients
David Galas/ISB
DJ-1, PINK-1, a-Synuclein
mouse models of PD
Manuel Buttini
The LCSB
Parkinson's Disease
Research Program
PD-network analysis in
SH-SY5Y cells
Paul Antony
Patrick May
Animal and Cellular Models of PD
Neuron-Astrocyte-Microglia Crosstalk
Alessandro Michelucci
iPS-cells
from PD-patients
Lasse Sinkkonen
Comparative Human-Mouse Systems Analysis
Antonio del Sol
Avrind Tallam
Computational Models
of PD
A PD-SBGN-map
SBI & LCSB
A kinetic model of PD related ROS generation
Alexey Kolodkin

9. Organisational structure: Research groups
Experimental Biology
(Sept 2009)
Endocrinology
(February 2011)
Metabolomics
(Sept 20010)
Bioinformatics
(April 2011)
Eco-Systems Biology
(October 2011)
Computational Biology
(February 2010)
Machine Learning
(November 2010)
4/25/2017

10. Bioinformatics and Computational Biology
Reinhard Schneider
Antonio del Sol
Nikos Vlassis

11. Organisational Structure: Translational Research
Jochen Schneider
20 % Clinic
80 %
LCSB
Nico Diederich
90 %
Clinic (CHL)
10 %
LCSB
Carine de Beaufort
75 %
Clinic (CHL)
25 %
LCSB

12. Experimental Models of Parkinson´s disease

13. Eco-Systemsbiology in the Gut

14. Technology Focus: Metabolomics
LPS
The Karsten Hiller-Team
Alessandro Michelucci
4/25/2017

15. LCSB: The Integration within the UL
Professorships
Projects
Personnel
Teaching
Infrastructure
Projects
Students
IT infrastructure
LSRU
LCSB
CSC
Link to LSRU, CSC, Doctoral school
We have joint grants UL
Joints AFR grants
Joint student ships
Joint projects CSC
Doctoral School
LCSB and LSRU PhD students

16. LCSB: The National Collaborations The Personalised Medicine Consortium
Patients Clinical Studies
Sample collection - processing - storage
Metabolomics Imaging Bioinformatics Computational Biology
Proteomics Clinical Trial Centre

17. Personalized Medicine Consortium (PMC)
Parkinson Disease Team
Diabetes Disease Team
Cancer Disease Team
In each team: 2-3 clinicians and 2-3 basic scientists
Nico Diederich
Rudi Balling
Carine de Beaufort Jochen Schneider
Guy Berchem
Bruno Domon
Team Leaders
Marek Ostaszewski
tbd
tbd
Project Manager

18. LCSB: The International Collaborations
Systems Biology
(ISB-Seattle)
Microfluidics (Univ.-Arizona)
PD-Disease Map
(Kitano-Tokyo)
Mouse Models (HMGU-Munich)
Metabolic Networks (MIT-Boston)

19. LCSB: The challenges
Develop a competitive Parkinson´s Disease research programme 1
Develop a bioinformatics and computational biology core 2
Establish appropriate infrastructure and technology platforms 3
Develop an attractive PhD-programme in Systems Biomedicine 4
Establish LCSB as an attractor for industrial cooperations 5