1. Brenda Poulter International Applications Specialist Thailand November 2004

2. Agenda Overview of SciFinder Content –Databases –Currency Search Examples –Topic –Author –Structure Additional topics and Hands on practice

3. Databases of SciFinder CAplus CASREACT CHEMCATS CHEMLIST MEDLINE/OLD MEDLINE REGISTRY

4. CAplus A CAS literature database containing references to research published in journals, patents, and other sources Contains Bibliographic, Abstract and Indexing Information – all searchable 1907 to present (some 1800’s) Over 23,650,000 records Updated daily

5. Medline/Old Medline A literature database containing references to Medical research published in journals Contains Bibliographic, Abstract and Indexing Information – all searchable 1953 to present About 14,500,00 references Updated 4 times per week

6. Registry Substance Database containing CAS RN, Structures, Chemical Names, Properties, Sequences 1957 to present Over 73 Million substances

7. CASREACT Database of Reactions 1840 to present 8,517,229 Single- and multi-step reactions Search full or half reactions Search Reactants, Reagents, Products, catalysts, any Role

8. CHEMCATS Quickly and easily obtain current information on commercially available chemicals and their worldwide suppliers More than 8.1 million products –734 suppliers –834 catalogs Updated upon receipt of new catalog

9. CHEMLIST Regulatory information from 19 Government Regulatory lists around the world 235,034 Inventoried/regulated substances Updated Weekly

10. Sources of SciFinder Over 9,000 journals monitored Patents (50 patent organizations) Technical disclosures Conference proceedings Technical reports Books Dissertations Reviews Meeting abstracts Web preprints IP.com Journal Electronic-only journals etc

11. Currency of SciFinder Updated Daily 1829 Core Journals (over 9000 total) –Bib and abs data within 5 days of receipt –Fully indexed within 21-28 days 7 core patent organizations (50 total) –Bib and abs data within 2 days of publication –Fully indexed within 27 days

12. SciFinder Improves the Process

13. SciFinder Saves Time

14. SciFinder Provides Current Information

15. SciFinder Exposes New Research

16. SciFinder Makes Searching Easy

17. Explore Topics

18. Searching by Company/Organization

19. Chiang Mai Search Results

21. Limitation by Author

22. Analysis by topics of Interest

23. Index term analysis

24. Get Related Information

25. Get Related feature Starting your search from a text explore Obtain all the substances indexed in the reference list –Answer set must be <1000 references –Refine with structure fragments or calculated properties Obtain the older cited references or forward citing references –Answer set must be <500 references

26. Citation searching The CAplus database includes citations from journal and patent references –Only from 1998-present 1997 is in progress –From roman script sources –Over 100 million citations Older references can be searched as citing references –Results limited to 1998-present

28. Author Search

29. Author Candidates

31. Full Text Patent

32. Citing References

33. Analysis of those who referenced paper

35. Better substance searching Pharmaceutical compounds are seldom simple neutral compounds Beware that salts and mixtures may have their own CAS Registry number Better to search known compound as an exact structure that as a name –Includes different stereoisomers, salts and mixtures Can copy/paste a CAS Registry to import the structure

36. Explore by Structure Search

37. Additional options allow for The inclusion or exclusion of Certain substance classes.

38. Explore by Structure Search

39. Analyze and Refine

40. Analyze features

41. Analyze Features

42. Refine Substances

43. Explore by Structure Search

44. Styrene-Isoprene polymers

45. With additional components: 573 Not possible to limit the maximum number of components

46. Without addl. components: 22 May include some oligomers and radio- labeled compounds

47. Searching by MF For addition polymers and most condensation polymers put the molecular formula of the monomers, separated by dots, within brackets and close with an “X” –(C8H8)x for styrene homopolymer –(C8H8. C5H8)x for styrene-isoprene polymers For structural repeating units of symmetric condensation polymers put the formula of the repeating unit within brackets and close with an “N” –(C14H12O4)n for polybutylene terephthalate –(C2H4O)nCH4O for  -methyl-  -hydroxy PE

48. Results for (C8H8. C5H8)x

49. Coordination Compounds Molecular Weight Easily search coordination compounds with either a molecular weight or a structure.

50. Coordination Compounds Structure and Refinement The additional options button allows for refinement of answers prior to the search.

57. References to Related Structures

70. Reaction Searching

71. Limiting Reaction Results

72. Reaction Results Screen

73. Retro Synthesis and Additional Information

75. Reaction Searching with functional Groups

76. Reactions Containing Phenol

77. View Change of Reaction Answers Reaction view may be changed. View / One reaction per reference.

78. Grouped Reaction Answer Reactions may be viewed as one representative reaction per reference. To see all reactions in the reference, click on link

79. Searching by substance name

81. Behind the Research Topic Explore feature Takes natural language query and search concepts in CAplus and Medline Concepts are identified using the natural adjectives and filler words Concepts are checked for chemical names –Searched both as name and as CAS RN Various combinations of terms as candidates –Exact phrase for a simple question –Terms closely associated in the text (same sentence) –Terms anywhere in the text (same document)

82. How to add synonyms SciFinder includes many different word spellings, abbreviations and many synonyms –Not comprehensive ; please consult your answers for terms not highlighted in blue Use brackets to indicate a synonym to a particular concept –E.g., drug analysis (pharmaceutical analysis) –Could use “OR” in simple cases

83. More Research Topic features Can use a CAS Registry Number in a natural phrase Can use words to exclude a concept –Refine by research topic can even start with a NOT operator Use quotes to find words as entered Use WITH when “anding” a list May use AND when searching There are limits to the complexity of your search statement

84. Topic Search of Liver fluke

85. Refining by Thailand References

86. Limit by Thailand

87. Topic searching using WITH

88. Getting Related Substances

89. Substances found within papers

90. Refine by Structure

92. Browse Table of Contents

95. ChemPort