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Langerhans Cell Histiocytosis: Growth Hormone Treatment over 3 years in KIGS Simon J Howell KIGS 10 Year Book, 1999.

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Presentation on theme: "Langerhans Cell Histiocytosis: Growth Hormone Treatment over 3 years in KIGS Simon J Howell KIGS 10 Year Book, 1999."— Presentation transcript:

1 Langerhans Cell Histiocytosis: Growth Hormone Treatment over 3 years in KIGS Simon J Howell KIGS 10 Year Book, 1999

2 S J Howell - KIGS 10 Year Book, 1999 Baseline characteristics of 82 KIGS patients with Langerhans cell histiocytosis TSH, thyroid-stimulating hormone; ACTH, adrenocorticotrophic hormone; LH, luteinising hormone; FSH, follicle-stimulating hormone; DI, diabetes insipidus

3 S J Howell - KIGS 10 Year Book, 1999 Response to GH treatment of patients with LCH (cross-sectional data for 3 years) (1/4)

4 S J Howell - KIGS 10 Year Book, 1999 Response to GH treatment of patients with LCH (cross-sectional data for 3 years) (2/4)

5 S J Howell - KIGS 10 Year Book, 1999 Response to GH treatment of patients with LCH (cross-sectional data for 3 years) (3/4)

6 S J Howell - KIGS 10 Year Book, 1999 Response to GH treatment of patients with LCH (cross-sectional data for 3 years) (4/4)

7 Response to GH treatment of patients with LCH (longitudinal data for 3 years) S J Howell - KIGS 10 Year Book, 1999 MPH, mid-parental height (1/4)

8 Response to GH treatment of patients with LCH (longitudinal data for 3 years) S J Howell - KIGS 10 Year Book, 1999 MPH, mid-parental height (2/4)

9 Response to GH treatment of patients with LCH (longitudinal data for 3 years) S J Howell - KIGS 10 Year Book, 1999 MPH, mid-parental height (3/4)

10 Response to GH treatment of patients with LCH (longitudinal data for 3 years) S J Howell - KIGS 10 Year Book, 1999 MPH, mid-parental height (4/4)

11 S J Howell - KIGS 10 Year Book, 1999 Response to GH replacement; comparison of patients with idiopathic GHD and with GHD associated with LCH n/a, not available (Ranke and Guilbaud 1991) (1/3)

12 S J Howell - KIGS 10 Year Book, 1999 n/a, not available (Ranke and Guilbaud 1991) Response to GH replacement; comparison of patients with idiopathic GHD and with GHD associated with LCH (2/3)

13 S J Howell - KIGS 10 Year Book, 1999 n/a, not available (Ranke and Guilbaud 1991) Response to GH replacement; comparison of patients with idiopathic GHD and with GHD associated with LCH (3/3)

14 S J Howell - KIGS 10 Year Book, 1999 a Corresponds to the start of the first year of GH treatment b GH doseand frequency of injections are median values based on the whole of the first year of GH therapy c The range quoted for pubertal patients in the cross-sectional group is the percentage who had entered puberty at the start and at the end of the first year d Data from only 76 patients e Data from only 15 patients Factors influencing first-year height velocity during GH therapy


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