1. PneumoNP presentation Nanotherapeutics to treat antibiotic resistant Gram- negative respiratory infections

2. PneumoNP presentation Introduction A European research project Nanotherapeutics to treat antibiotic resistant Gram-negative pneumonia infections Funded under the Seventh Framework Programme Collaborative project More than 5.5M€ 2014-2017 Klebsiella pneumoniae as proof of concept

3. Objectives Project expected outcomes: a new inhablable drug composed of a nanotherapeutic system: an active antibacterial and a nanocarrier; a new aerosol technology specifically developed for the nanotherapeutic system; an innovative efficiency-efficacy test to follow-up the treatment; And a new diagnostic kit for the rapid and multiplex identification of bacteria causing respiratory infections. PneumoNP presentation

4. Work plan PneumoNP presentation

5. Partners PneumoNP presentation Research institutes Universities SMEs Entreprise Clinicians 11 partners 6 countries : Spain, Danemark, Germany, Italy, France, The Netherlands Each with a distinctive role

6. PneumoNP towards OI model PneumoNP presentation PneumoNP position in the nanomedicine value chain strenghtened by: 1.Good cooperation between all stakeholders 2.Integration of regulatory issues from the early stages of development 3.Awareness of scalability and GMP production

7. Economic impact Nanomedicine is a key component for pharma companies willing to maintain their competitiveness today. Expected market size (M€)201520202025 Non-invasive delivery of protein nanomedicines010,000 ± 5,00020,000 ± 10,000 Non-invasive delivery of nucleic acid based nanomedicines 05,000 ± 2,00010,000 ± 5,000 PneumoNP presentation $63.8 billion 2010 $130.9 billion 2016 Expected growth of the nanomedicine market if research is correctly oriented and pushed forward Urgent need of MDR antibacterials and lack of new agents reaching the market..

8. Questions ? Find us PneumoNP presentation You can find out more about the PneumoNP project on our website. Follow us on Twitter to get the latest news, or on LinkedIn to share your expertise with us! @PneumoNP PneumoNP www.pneumonp.eu ?