1. Mrs. Anna Ward James Martin MS

2. 1. How many males are present? 2. How many females are present? 3. How many generations? 4. How many children does the first generation (I) couple have? 5. How many marriages are represented? 6. How many males have the disease? 7. How many females have the disease? In the Pedigree to the Right, tell me….

3. Don’t forget Pass Expectations Schedule for today: 9:15 - 10:15 Cougar Time 10:20 - 11:20 2nd Period 11:25 - 12:55: 3rd Period 12:20 - 12:50 Lunch 1:00 - 1:55 4th Period 2:00 - 3:00 5th Period 3:05 - 4:15 CELEBRATION! (Johnson & Rodriguez's Room)

4. Huntington’s Disease Sickle Cell Anemia Hemophilia Create your own PEDIGREE

5. Huntington's disease is a genetic disorder passed down through families in which nerve cells in certain parts of the brain waste away, or degenerate.

6. If one of your parents has it, you have a 50% chance of getting it. Onset of the symptoms usually starts around age 40. One of the common traits marked in pedigrees First Genetic Disease Mapped to a Chromosome (#4)

7. http://www.youtube.com/watch?v=65xf1olEpQM

8. Why do you think it would be important to use a Pedigree to track Huntington’s Disease??? What do you notice about this Pedigree?

9. Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shape. (Red blood cells are normally shaped like a disc.) http://www.youtube.com/watch?v=iKQmQHh4E2w&f eature=related http://www.youtube.com/watch?v=iKQmQHh4E2w&f eature=related http://www.youtube.com/watch?v=qe59ar-GZmg

10. Sickle Cell Pedigree: HOW IS THIS DIFFERENT FROM THE PEDIGREE FOR HUNTINGTONS?

11. Hemophilia refers to a group of bleeding disorders in which it takes a long time for the blood to clot. Known as the “ROYAL DISEASE” from the infamous Russian Royal Family

12. http://player.discoveryeducation.com/index.cfm?guid AssetId=A6AC1338-DEC9-4AA1-AEED- 18BCAE0239DB&blnFromSearch=1&productcode=US http://player.discoveryeducation.com/index.cfm?guid AssetId=A6AC1338-DEC9-4AA1-AEED- 18BCAE0239DB&blnFromSearch=1&productcode=US

14. Think of a trait that some (but not all) of your family members carry. Some examples may be: Left-Handedness Curly Hair Tongue Rolling Widow’s Peak Attached Earlobes Freckles Allegies Cleft Chin …….

15. Begin By Drawing your family members, using a CIRCLE—Women/girls SQUARE—Men/Boys DO NOT SHADE ANYTHING AT THIS POINT Here is a diagram to help you remember how to draw one:

16. If anyone is deceased, Make a diagonal slash mark through their circle or square. Then use a Marker to Color in any family member with the trait. If you do not know the trait for sure, you can take it home and complete it over the weekend.

17. Label your pedigree with your name, your family name Place a “key” at the bottom or side indicating what each shape means.