1. LIVER PHYSIOLOGY & PATHOPHYSIOLOGY TILLY ADAMSON HELEN TURNBULL-ROSS

2. MAJOR FUNCTIONS OF THE LIVER DRUG METABOLISM AND DETOXIFICATION EXCRETION OF BILIRUBIN SYNTHESIS OF PLASMA PROTEINS PRODUCTION, STORAGE AND SECRETION OF BILE IMMUNE FUNCTIONS CHOLESTEROL PROCESSING ENERGY METABOLISM AND SUBSTRATE CONVERSION

3. PHASES OF DRUG METABOLISM PHASE I – ADDITIONAL FUNCTIONAL GROUP PHASE II – CONJUGATION PHASE III - EXCRETION

4. PHASE I PROVIDES FUNCTIONAL GROUP INCREASE POLARITY PROVIDE A SITE FOR PHASE 2 REACTIONS OXIDATION / REDUCTION / HYDROLYSIS

5. PHASE II CONJUGATION ATTACHMENT OF LARGE CHEMICAL GROUP PRODUCES HYDROPHILIC, MORE PHARMACOLOGICALLY INACTIVE COMPOUND  MORE EASILY EXCRETED

6. PHASE III EXCRETION VIA CIRCULATION / BILE

7. WHAT IS THE HALLMARK OF LIVER DISEASE? ENCEPHALOPATHY

8. WHAT ARE THE CAUSES OF LIVER DISEASE? ALCOHOL FAT IRON VIRUS

9. FATTY LIVER DISEASE NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD) - MAY BE ASYMPTOMATIC NON ALCOHOLIC STEATOHEPATITIS (NASH) - MORE SEVERE AND CAN PROGRESS AND LEAD TO CIRRHOSIS

10. CIRRHOSIS ADVANCED LIVER DISEASE LIVER IS PERMANENTLY DAMAGED AND UNABLE TO FUNCTION NORMALLY REPLACEMENT OF LIVER TISSUE BY FIBROSIS  SCAR TISSUE

11. THANKS! ANY QUESTIONS?