Presentation is loading. Please wait.

Presentation is loading. Please wait.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,

Published bySara Maxwell Modified over 9 years ago

Similar presentations

Presentation on theme: "The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,"— Presentation transcript:

1 The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Gillian M. Tannahill, Esme C. Hatchell, Ian J. Majewski, Toru Okamoto, Renwick C.J. Dobson, Douglas J. Hilton, Jeffrey J. Babon, Nicos A. Nicola, Andreas Strasser, John Silke, Warren S. Alexander Immunity Volume 39, Issue 3, Pages 443-453 (September 2013) DOI: 10.1016/j.immuni.2013.06.018 Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

2 Figure 1 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

3 Figure 2 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

4 Figure 3 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

5 Figure 4 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

6 Figure 5 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

7 Figure 6 Immunity 2013 39, 443-453DOI: (10.1016/j.immuni.2013.06.018) Copyright © 2013 Elsevier Inc. Terms and Conditions Terms and Conditions

Download ppt "The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet,"

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages 671-680 (November 2011) DOI: 10.1016/j.immuni.2011.11.001.

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni
Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.

Bacterial Entry to the Splenic White Pulp Initiates Antigen Presentation to CD8+ T Cells Taiki Aoshi, Bernd H. Zinselmeyer, Vjollca Konjufca, Jennifer.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages 733-745 (September 2009) DOI:

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages 12-24 (July 2010) DOI: 10.1016/j.immuni.2010.07.006.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,
Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.
Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages 275-291 (March 2014) DOI: 10.1016/j.stem.2014.02.006.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.
Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases Xuehua Zhong, Jiamu Du, Christopher J. Hale, Javier Gallego-Bartolome, Suhua.

Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases Xuehua Zhong, Jiamu Du, Christopher J. Hale, Javier Gallego-Bartolome, Suhua.
The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.
The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2- Dependent Recruitment of Inflammatory Monocytes Yun-Gi Kim, Nobuhiko Kamada,

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2- Dependent Recruitment of Inflammatory Monocytes Yun-Gi Kim, Nobuhiko Kamada,
Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages 654-666 (March 2016) DOI: 10.1016/j.molcel.2016.01.028.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages 26-39 (July 2012) DOI: 10.1016/j.neuron.2012.06.018.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Similar presentations

Ads by Google