1. Reversible cell injury  cellular swelling (Hydropic changes)  Fatty changes Irreversible cell injury  Necrosis  Apoptosis Cell Injury

2. Intracellular Accumulation and Extracellular Deposits  Fatty infiltration (steatosis)  Amyloidosis  Hyalinosis

3. Gross Pathology Lesson 2 1)Normal liver 2)Fatty changes (steatosis) of the liver 3)Coagulative necrosis (renal infarction) 4)Coagulative necrosis (splenic infarction) 5)Myocardial infarction (recent infarction ) 6)Liquifactive necrosis (brain infarction) 7)Caseation necrosis 8)Amyloid liver 9)Anthracosis of lung

4. Normal liver

5.  Section in the liver shows  enlarged and has a pale yellow, soft and greasy appearance, seen both on the capsule and cut surface.  Diagnosis : liver fatty change.

6. Coagulative necrosis ( renal infarction) Section in the kidney shows a wedge-shaped pale area of coagulative necrosis (infarction) in the renal cortex Diagnosis :

7. Diagnosis :Coagulative necrosis ( splenic infarction) Section in spleen shows Two large infarctions (areas of coagulative necrosis) infarcts are often wedge-shaped with a base on the organ capsule.

8. Myocardial infarction An opened heart showing Deeply hemorrhage and mural thrombus in anterior wall and apex diagnosis : massive myocardial infarction

9.  Section in the brain shows  an irregular depressed area with complete lost of tissue  Diagnosis :Old brain infarction

10. Caseation necrosis Section in the lung shows  The hilar lymph node (2x2 ) cm, has a cheesy tan to white appearance.  Diagnosis: caseous necrosis in a hilar lymph node infected with tuberculosis

11. Amyloid liver Section of the enlarged liver shows reticulated pale waxy material between liver cells

12. Exogenous pigment Anthracosis of lung Patches of blackish areas of the lung Diagnosis : anthracosis of lung

13. Histopathology Slides for Lesson2  Hyalinosis of spleen  Amyloid kidney  Liver steatosis (fatty liver)  pulmonary thrombus  true thrombus

15. Section in the spleen shows:  Hyaline degeneration affecting the central arterioles of lymph follicles.  The wall of arterioles become structureless homogenous,pink,thick and narrow lumen.  Diagnosis: Hyalinosis of spleen

18. Section in the kidney shows: Homogenous pink amyloid deposits in the wall of arterioles which appear thick with narrow lumen. Amyloid deposit in the basement membrane of glomerular capillaries. Some glomeruli are partially or completely replaced by pink amyloid deposit. Amyloid deposit in basement membrane of the collecting tubules with albumin casts in tubular lumen. Diagnosis Amyloid kidney

19. Amyloid Kidney

21. Section in the liver shows:  Empty vacuoles in the cytoplasm of the liver cells which appear distended. These vacuoles were occupied by fat which had dissolved in xylol during preparation.  The nuclei of the cells are pushed by the fat and become flattened giving the cell signet ring appearance.  Diagnosis: Liver steatosis (fatty liver)