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Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light.

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Presentation on theme: "Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light."— Presentation transcript:

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2 Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chains

3 Immunoglobulin Isotypes Occurrence Importance Ig levels Definition Location IgM (kappa) IgG1 (kappa)

4 Immunoglobulin Allotypes Definition - Antigenic determinants specified by allelic forms of the Ig genes Location Occurrence – Source of anti- allotypic Abs IgG1 (kappa) Person 2 IgG1 (kappa) Person 1

5 Human Immunoglobulin Allotypes Nomenclature – G1m(3) – Km(1) - G2m(23)

6 Human Immunoglobulin Allotypes IgG – 25 Allotypes IgA2 – 2 Allotypes k (L) – 3 Allotypes

7 Immunoglobulin Idiotypes Definition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificity

8 Immunoglobulin Idiotypes Definition Location IgG1 (kappa) Person 1 anti-B IgG1 (kappa) Person 1 anti-A

9 Immunoglobulin Idiotypes Definition Location Importance V region marker Regulation of immune responses

10 Immunoglobulin Idiotypes Definition Location Importance V region marker Regulation of immune responses Vaccines

11 AgIdanti-Id + - Anti-Idiotype Vaccines AgIdanti-Id +

12 Anti-Idiotype Vaccines Ag + Ab Ag / Ab + Ab = Ag Anti-Id-Ab Vaccine

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