1. Cure of Colitis by CD4 + CD25 + Regulatory T Cells Barrette Kathleen – Dreesen Erwin Mottet C, Uhlig HH, Powrie F

2. CD4 + CD45RB low CD45RB high CD4 - CD25 + CD25 -

3. CD4 + CD45RB low CD45RB high CD4 - CD25 + CD25 - Regulatory T cells (T reg ) As therapeutic agents?

4. Conditions -Inhibit ongoing T cell responses -Reverse established pathology

5. Experimental protocol

11. CD4 + CD25 + T R cells reverse wasting disease

18. CD4 + CD25 + T R cells reverse colitis

23. CD4 + CD25 + T R cells reverse wasting disease & colitis

24. CD4 + CD25 + T cells home to the MLN & colon * P < 0,05 *

25. CD4 + CD25 + T cells home to the MLN & colon

26. The progeny of CD4 + CD25 + T cells proliferate in MLN & colon

28. CD4 + CD25 + T cells are in contact with CD11c + cells and CD4 + T cells in vivo