1. Blood lab

2. Blood composition Plasma – fluid, gives volume contains antibodies
Platelets – helps in clotting of blood
White blood cells – used in defense against foreign invaders
Red blood cells – carry oxygen
Blood after it has been centrifuged

3. Blood Genetics THREE TWO FOUR SIX In blood type genetics*, there are:
____________ genes OR alleles that
Produce ____________ blood proteins that
Result in ____________ blood types that
Establish ____________ genotypes
THREE
TWO
FOUR
SIX
*See wkst #4

4. TERMS TO KNOW Protein- antigen (ag) or agglutinogens
Antibodies- agglutinin- fight against foreign particles
Coagulation: Blood clotting
Agglutination: Blood clumping
RBC = Red blood Cell

5. RBC Has Antigens

6. Blood Groups Are Based On RBC Antigens (Ag)
‘A’ Ag
Rh+ Antigen

7. Blood Groups: B+ and B-
‘B’ Ag
Rh+ Antigen

8. Blood Groups: AB+ and AB-
‘A’ Ag
‘B’ Ag
Rh+ Antigen

9. Blood Groups: O+ and O-
Rh+ Antigen

10. Plasma Has Antibodies

11. Remember RBC Has Antigens

12. Antibodies Can Bind To Antigens

13. Clumping of Blood

14. RBC Antigen (Agglutinogen) A B Plasma Antibodies (Agglutininins)
Possible Genotypes: AA AO BB BO AB OO
RBC Antigen (Agglutinogen) A B
None
Plasma Antibodies (Agglutininins)
Anti – B
Anti – A
both
Reaction with Anti – A
YES
Reaction with Anti – B NO
YES NO NO
YES
YES NO

15. RECIPIENT DONOR + + - - + + - - + + + - - - - - Type A (anti B) Type B
(anti A)
Type AB
(none)
Type 0
(anti A & Anti B) A B AB O
DONOR - + - + + - - + + + - + - - - -

16. Rh Factor RR, Rr rr yes no anti Rh no Blood Type Positive Negative
Genotype(s)
Antigens (yes or no)
Agglutinins (antibodies)
RR, Rr rr
yes no
anti Rh no
Moms that have Rh negative blood will have antibodies/ fight against a baby with the Rh protein (positive).

17. 1st Baby Is Rh + ; Mom is Rh -
Baby’s blood enters mom’s blood, transferring Rh+ Antigens to mom

18. 1st Baby Is Rh +; Mom Is Rh -
Mom Makes Antibodies against Rh+ Antigens In Her Blood

19. 2nd Baby Is Also Rh +
Mom’s Antibodies Attack The RBC’s In The 2nd Baby

20. Erythroblastosis Fetalis

21. Anti Rh + Antibodies (Rhogam)

22. Rhogam Destroys Rh + Antibodies In Mom

23. 1st Baby Is Rh +
Rhogam prevents Mom From Making Antibodies against Rh+ Antigens

24. 2nd Baby Is Also Rh +
With Rhogam, Mom’s Blood Does Not Attack The RBC’s In The 2nd Baby

25. Jaundice in Infants
Complications Due to ABO Incompatibility Are Rare!

26. TYPE O TYPE A TYPE B TYPE AB RXN
NO RXN
TYPE O
TYPE A
TYPE B
TYPE AB