1. DERIVATIVE WEIGHTED ACTIVE INSULIN CONTROL ALGORITHMS AND TRIALS J. Geoffrey Chase, Geoffrey M. Shaw, Carmen V. Doran, Nicolas H. Hudson and Katherine T. Moorhead Department of Mechanical Engineering, University of Canterbury Department of Intensive Care Medicine, Christchurch Hospital 5th IFAC Symposium on Modelling and Control in Biomedical Systems Melbourne, Australia

2. 2 Compartment IV Model 1.Collect OGTT data from IGT patient (Day 1) 2.Fit model parameters p 1 and p 4 to simulate IGT patient. 3.Develop control gains K p and K d, with K d >> K p 4.Implement controller on the patient (Day 2) Method

3. Clinical Trial Results GlucoCard error = 7% First known human trials of this type Proof of concept clinical trials started with good results Increased model understanding Necessary additional dynamics Patient Predicted Insulin (U) Actual Insulin (U) Difference (%) 14.504.43-1.55 24.904.50-8.16