1. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH

2. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis.

3. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Biology of tumor growth. Kinetics of tumor cell growth. Tumor angiogenesis. Tumor progression and heterogeneity. Tumor invasion and spread.

4. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Doubling time : equal or more than that of normal cells. Growth fraction : cells in replicative pool, rarely >20%. Production vz loss :

5. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Angiogenesis Tumor-associated angiogenic factors : -bFGF, VEGF …… etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin, thrombospondin ( p53 upregulated).

6. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Clinical implications: 1- cancer therapey : Targeting cycling cells. Effect of radiation & debulking. 2- latent period of tumors : Months to years.

7. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Progression and Heterogeneity.

8. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Invasion and Spread. Methods of spread : - Direct. -Through blood vessels. -Through lymph vessels.

9. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

10. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

11. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

12. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

13. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

14. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

15. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

16. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

17. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

18. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

19. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

20. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

21. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

22. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

23. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

24. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

25. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of Cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis.

26. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens.

27. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens.

28. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens

29. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens

30. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens

31. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens

32. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens

33. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH

34. Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemotherapy Induced Malignancies