1. Introduction PA 481 C Clinical Anatomy & Physiology Dr. Tony Serino “The nature of the body is the beginning of medical science.” Hippocrates ~350 B.C.E

2. Anatomy & Physiology Anatomy –study of body structures and their relationships Physiology –study of body mechanisms (homeostasis) Andreas Vesalius’s De Humani Corporis Fabrica (On the Fabric of the Human Body) 1543 AD; was the founding work on which Anatomy is based

3. Types of Anatomy Regional Anatomy –study of body structure by focusing on a specific part, region, or subregion including all of its systemic features. Useful for: –Understanding 3D arrangements of structures –Layers of the body –The relationships among its structures Surface Anatomy –study of body surface, referencing what lies beneath –Useful for visualization of internal anatomy –Used in medical diagnosis (palpation) and treatment Systemic Anatomy –study of body structure focusing on organ systems –The way most undergrad anatomy is taught

4. Systems and related Medical Field IntegumentaryDermatology SkeletalOsteology JointsArthrology MuscularMycology NervousNeurology CirculationAngiology HeartCardiology DigestionGastroenterology RespiratoryPulmonology UrinaryUrology ReproductiveGynecology (female), Andrology (male) EndocrineEndocrinology Orthropedics

5. Body Plan Tube within a tube Internal vs. External environment Bilateral Symmetry Dorsal Hollow Nerve cord

6. Body Cavities: spaces within internal environment (Peritoneal cavity)

7. Serous Membranes & Mesenteries Mesothelium (simple squamous epithelium) lining the body cavities (parietal) and their organs (visceral) Each membrane is named for the cavity it lines Form double membranes which suspend organs within cavities True mesenteries connect the body wall to the organ Ligaments connect organ to organ

8. Visceral vs. Parietal Parietal membrane Body Cavity filled with serous fluid Visceral membrane

9. Pericardium

10. Pleura Parietal Pleura Visceral Pleura Pleural cavity

11. Parietal Peritoneum Peritoneum Visceral Peritoneum Peritoneal cavity

12. Body Plan Body Planes Tube within a tube Bilateral Symmetry Dorsal Hollow Nerve cord Anatomical Position

13. Body Plan Tube within a tube Bilateral Symmetry Dorsal Hollow Nerve cord Anatomical directions.

14. Anatomical Variation Anatomy described here represents 70% of the population Expect variation in specimens Veins vary most, arteries and nerves the least. Ooops! Didn’t expect this in the abdomen. Things one never wants to hear in the OR.

15. Homeostasis Maintenance of a constant internal environment Uses a reflex arc to self regulate Reflex functions to maintain a certain set point with a narrow physiological range

16. Set Point and Range

17. Factors Affecting Homeostasis Feedback –negative or positive Feed-forward regulation Acclimatization Biorhythms

18. Body Fluids Transcellular fluids are filtrates of the plasma

19. Important Ions

20. Systems Overview Next few lectures will deal with anatomy and physiology that is represented throughout most regions of the body. Systems include: Integument, Skeletal, Muscular, Vessels (CV and Lymphatic), and Nervous Systems