1. Global Forum for Health Research Mumbai, September 12 to 16 2005 1 Rob Ridley Director, TDR Sustaining Priority Research for Neglected Tropical Diseases

2. Global Forum for Health Research Mumbai, September 12 to 16 2005 2 To undertake research, development and evaluation of new and improved tools and interventions to fight major tropical diseases To strengthen research capabilities in countries where these diseases are endemic –enhanced stakeholdership / ownership of research TDR 'twin' Mission

3. Global Forum for Health Research Mumbai, September 12 to 16 2005 3 A vicious cycle

4. Global Forum for Health Research Mumbai, September 12 to 16 2005 4 Many 'Neglected Diseases' Infectious and Parasitic diseases 10 904 (000) HIV/AIDS 2 777 ¨ Diarrhoeal diseases 1 798 ¨ Tuberculosis 1 566 ¨ Malaria 1 272 ¨ Childhood diseases 1 124 ¨ STI (excluding HIV) 180 ¨ Meningitis 173 ¨ (Other) Tropical Diseases 129 ¨ Hepatitis B 103 ¨ Hepatitis C 54 ¨ Dengue 19 ¨ Japanese encephalitis 14 ¨ Intestinal nematode 12 ¨ Leprosy 6 ¨ Mortality Estimates for 2002 (World Health Report 2004)

5. Global Forum for Health Research Mumbai, September 12 to 16 2005 5 'Neglected' Diseases affect 'Neglected' Populations

6. Global Forum for Health Research Mumbai, September 12 to 16 2005 6 Priority Setting

7. Global Forum for Health Research Mumbai, September 12 to 16 2005 7 Strategy ?? Tropical Disease Burden Poverty Control/ Elimination Of Tropical Diseases Poverty reduction

8. Global Forum for Health Research Mumbai, September 12 to 16 2005 8 NIH, Trust, Research councils etc. Grand Challenges Innovation to Impact

9. Global Forum for Health Research Mumbai, September 12 to 16 2005 9 Need to sustain and increase basic science funding

10. Global Forum for Health Research Mumbai, September 12 to 16 2005 10 Product Development

11. Global Forum for Health Research Mumbai, September 12 to 16 2005 11 Examples of public private partnerships that have delivered new tools

12. Global Forum for Health Research Mumbai, September 12 to 16 2005 12 Microbicides MMV IAVI FIND GATB MVI EDCTP DNDi Innovation to Impact – product development

13. Global Forum for Health Research Mumbai, September 12 to 16 2005 13 8 new drugs anticipated by 2010 Proposed fund of $200M per year to complement PPP's Product Development Activities Need Sustaining

14. Global Forum for Health Research Mumbai, September 12 to 16 2005 14 Much variation by disease (e.g. Gates)

15. Global Forum for Health Research Mumbai, September 12 to 16 2005 15 Evaluation and Implementation Research

16. Global Forum for Health Research Mumbai, September 12 to 16 2005 16 Onchocerciasis –Ivermectin and Community Directed Treatment Malaria –Home management of malaria strategies Visceral Leishmaniasis –Tools in place for 'elimination' programmes Examples of TDR – mediated evaluation and implementation research A critical area for future funding given increase of tools in pipeline

17. Global Forum for Health Research Mumbai, September 12 to 16 2005 17 New tools stimulate India / Nepal / Bangladesh to sign MoU for elimination of VL by 2015 Local ownership of research critical Recognition of significance of social, economic and behavioural research Research must be embedded in and owned by countries and integrated into health systems Inter-country coordination facilitated by WHO / SEARO / TDR Requires a co-ordinated approach by partners for maximal impact Example in progress Visceral Leishmaniasis

18. Global Forum for Health Research Mumbai, September 12 to 16 2005 18 Innovation to Impact

19. Global Forum for Health Research Mumbai, September 12 to 16 2005 19 Innovation to Impact

20. Global Forum for Health Research Mumbai, September 12 to 16 2005 20 Look beyond single issues Managing Interfaces

21. Global Forum for Health Research Mumbai, September 12 to 16 2005 21 Maintained funding for basic science, continued innovation and PPP product development –Better balance for more neglected diseases –Better management of translation research Enhanced Evaluation and Implementation Research for all diseases Enhanced coordination and interaction between initiatives, funding agencies, governments and regional bodies –Role for international agencies Challenges No. 1

22. Global Forum for Health Research Mumbai, September 12 to 16 2005 22 Look beyond single issues Cross-cutting issues

23. Global Forum for Health Research Mumbai, September 12 to 16 2005 23 Need capacity building coupled to capacity utilisation Need to enhance country participation, 'stakeholdership' and ownership of research Need to 'embed' the output of research activities within the institutions of developing countries Need to enhance capabilities of developing countries to engage in 'innovation' as well as implementation Challenges No. 2

24. Global Forum for Health Research Mumbai, September 12 to 16 2005 24 Use-inspired Research