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Published byRandell Clarke Modified over 9 years ago
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Chances & Challenges of Bioinformatics in TCM Prof. Qiao Yanjiang Zhang Yanling collean_zhang@163.com Beijing University of Chinese Medicine
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Outline Background Chances and Challenges Brief Idea of Our Work A Simple Example
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Puzzles in TCM
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Bioinformatics can do in TCM 1R4L from PDB Pathway form KEGG
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Integral and traditional Theory Thousands of years of clinical experience More than nine thousand material medica How to communicate with modern science? How to make a further progress? Chances
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Syndrome Differentiation Harmony & Wholism Challenges
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Brief Idea of Our Work
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DAHAHA/DAH/HE ACE177981886563525E-040.7916.02 AngII177981532491724900.0031.003.33 PDE4177981285312971680.0020.543.35 5-HT3177981278407222000.0020.493.14 HMG-CoA177981215337181360.0010.403.34 D : number of molecules in database A : number of active molecules in database H : number of hit molecules AH : number of active molecules in hitlist Virtual Screening
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Blue = medicine 1 Yellow = medicine 2 Green = medicine 3 Black= superposition of two webs Red= superposition of three webs Model of Cancer
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Herbs Compounds Formulas Formula= Herb 1 +Herb 2 +……+Herb n Herb= Compound 1 +Compound 2 +……+Compound j Formula = Compound 1 +Compound 2 +……+Compound m f ( ) ? ? ?
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Compounds Database of Fufang Danshen Tablets
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HMG -CoA T-cell PDE TNF ɑ COX2 AngII
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Thanks for Your Attention! We’re Waiting for YOU!
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