1. Chances & Challenges of Bioinformatics in TCM Prof. Qiao Yanjiang Zhang Yanling collean_zhang@163.com Beijing University of Chinese Medicine

2. Outline Background Chances and Challenges Brief Idea of Our Work A Simple Example

3. Puzzles in TCM

4. Bioinformatics can do in TCM 1R4L from PDB Pathway form KEGG

5. Integral and traditional Theory Thousands of years of clinical experience More than nine thousand material medica How to communicate with modern science? How to make a further progress? Chances

6. Syndrome Differentiation Harmony & Wholism Challenges

7. Brief Idea of Our Work

8. DAHAHA/DAH/HE ACE177981886563525E-040.7916.02 AngII177981532491724900.0031.003.33 PDE4177981285312971680.0020.543.35 5-HT3177981278407222000.0020.493.14 HMG-CoA177981215337181360.0010.403.34 D ： number of molecules in database A ： number of active molecules in database H ： number of hit molecules AH ： number of active molecules in hitlist Virtual Screening

9. Blue = medicine 1 Yellow = medicine 2 Green = medicine 3 Black= superposition of two webs Red= superposition of three webs Model of Cancer

10. Herbs Compounds Formulas Formula= Herb 1 +Herb 2 +……+Herb n Herb= Compound 1 +Compound 2 +……+Compound j Formula = Compound 1 +Compound 2 +……+Compound m f ( ) ? ? ?

11. Compounds Database of Fufang Danshen Tablets

12. HMG -CoA T-cell PDE TNF ɑ COX2 AngII

13. Thanks for Your Attention! We’re Waiting for YOU!