1. OMX

2. In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin- producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers) In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin- producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers) For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded Scientist of the Year in 1991 after successfully encapsulating strains of good bacteria as “Probiotics”. For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded Scientist of the Year in 1991 after successfully encapsulating strains of good bacteria as “Probiotics”.

3. is a LIVE microbial food is a LIVE microbial food medicine which beneficially medicine which beneficially improves and maintain human improves and maintain human intestinal microbial balance. intestinal microbial balance. is a LIVE microbial food is a LIVE microbial food medicine which beneficially medicine which beneficially improves and maintain human improves and maintain human intestinal microbial balance. intestinal microbial balance. Definition by the FAO/WHO Definition by the FAO/WHO “live microorganisms which when “live microorganisms which when consumed in ADEQUATE consumed in ADEQUATE AMOUNTS, confer a health effect AMOUNTS, confer a health effect on the host. on the host. Definition by the FAO/WHO Definition by the FAO/WHO “live microorganisms which when “live microorganisms which when consumed in ADEQUATE consumed in ADEQUATE AMOUNTS, confer a health effect AMOUNTS, confer a health effect on the host. on the host.

5. Effect of OMX capsule on Diarrhea in infants 3-24 months of age JRRMMC Randomized controlled trial. (2 Capsules a day) Intake of OMX Probiotics capsule (1capsule BID for 5 days), in addition to ORS, significantly reduced the duration of Diarrhea in children compared with those who only received ORS. The mean days Were shorter 3.17 days in the probiotic Group than in the non-probiotic group with 5.42 days. Design Outcome * Second Prize; PPS – Inter-subspecialty Convention 2006, Manila Presented: 1 st Asian Congress of Pediatric Research Tokyo, Japan 2006

6. Design Outcome Effect of OMX capsule as Adjunct in the treatment of Severe Pneumonia in infants 6-24 months Of age JRRMMC Randomized controlled trial Group 1 ampicillin & probiotics Group 2 probiotics only. (2 Capsules a day) Intake of OMX Probiotics capsule Significantly shortened the duration of Illness (cough, fever, rales, retractions, Wheezing), hospital stay and respiratory Symptoms with mean of 2.4 days in the Treatment group vs. 4.3 days in the control Group. Increase of appetite was also observed. *First Prize; PPS – Inter-subspecialty Convention 2006, Manila Presented: 3 rd Asian Congress Pediatric Infectious Disease, Bangkok, Thailand 2006 13 th Pediatric Infectious Disease Society of the Philippines, Cebu, 2006

7. Beneficial effects of probiotics, OMX capsule in Grade II Dengue Hemorrhagic Fever PCMC Randomized controlled trial Open label. (2 Capsules a day) Intake of OMX Probiotics capsule shows that patient did not progress to further deterioration of their condition and were able to have earlier normalization of their hematocrit and platelet count. HCT 3.94 (control group) & 2.16 days (experimental group). Platelet Count 5.50 (control group) & 3.3 Days (experimental group). Design Outcome Presented: 2 nd Congress of Asian Pediatric Research, Yokohama, Japan 2007

8. Presented: 25 th International Congress of Pediatrics Athens, Greece 2007 Effect of OMX Probiotic capsule on Immune Markers of Undernourished Filipino Children PCMC Randomized controlled trial Open label. (2 Capsules a day) Probiotics lead to significant weight gain (1 kilogram for the first week) and shorter duration of infections. Increase of appetite was also noted. Design Outcome

9. Effect of OMX, as adjunct treatment in Febrile Neutropenia among children 2 – 18 years of age. CSMC Double Blind Placebo Controlled Clinical Trial. OMX produced clinical reduction in mean body temperature, shorter duration of hospital stay and significantly increase in ANC count. Increase Appetite also was noted. With resolved cases of UTI, mucositis and diarrhea. Design Outcome * First Prize; 1.) CSMC Research Contest, 2008 2.) PSH&BT, September, 2008 2.) PSH&BT, September, 2008 Presented: Pediatric Academic Societies & 4 th ASPR, Honolulu, Hawaii, USA, 2009

10. OMX in the prevention of recurrent UTI in children with Urinary Tract Abnormalities PCMC Randomized Controlled Trial. OMX Probiotics prophylaxis was a s effective as antibiotic prophylaxis in children with urinary tract abnormalities; increase appetite was also noted. Design Outcome * First Prize; 1.) PCMC - Research Contest, 2009 2.) PPS – Research Contest, April, 2009 2.) PPS – Research Contest, April, 2009 Presented: Pediatric Academic Societies, 2009 Baltimore, Maryland, USA

11. The freeze drying process involves the removal of water by subjecting the bacteria to extremes of heat and cold and the application of vacuum. This drastic “ripping off” of water from a living organism disrupts its structure, function and internal environment. Addition of stabilizers and preservatives prior to freeze drying. Addition of stabilizers and preservatives prior to freeze drying. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Extensive damage to bacteria caused by freeze drying process. Extensive damage to bacteria caused by freeze drying process. Powder shelf life is short. Powder shelf life is short. Powder absorbs water, then bacteria become activated and die away. Powder absorbs water, then bacteria become activated and die away. Live bacteria in the powder have damaged walls and cannot grow properly. Live bacteria in the powder have damaged walls and cannot grow properly. Transport and storage is easier, but must be refrigerated. Transport and storage is easier, but must be refrigerated. Addition of stabilizers and preservatives prior to freeze drying. Addition of stabilizers and preservatives prior to freeze drying. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Extensive damage to bacteria caused by freeze drying process. Extensive damage to bacteria caused by freeze drying process. Powder shelf life is short. Powder shelf life is short. Powder absorbs water, then bacteria become activated and die away. Powder absorbs water, then bacteria become activated and die away. Live bacteria in the powder have damaged walls and cannot grow properly. Live bacteria in the powder have damaged walls and cannot grow properly. Transport and storage is easier, but must be refrigerated. Transport and storage is easier, but must be refrigerated. POWDERSPOWDERS (free powders and capsules)

12. LIQUID PREPARATIONS (Yoghurt, etc.) Liquid preparations offer major disadvantages which relate to the instability of free organisms while in solution, harsh methods of preparation such as pasteurization, and the corrosive action of the stomach’s acid. Short shelf life (few organisms remain alive in solution after several weeks) Short shelf life (few organisms remain alive in solution after several weeks) Friendly bacteria damaged by pasteurization Friendly bacteria damaged by pasteurization (exposure to high temperatures 60 to 80 deg. C) (exposure to high temperatures 60 to 80 deg. C) Severe bacterial cell damage occurs if centrifugation and chemicals are used. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Additives and preservatives are added to stabilize the bacteria in solution. Additives and preservatives are added to stabilize the bacteria in solution. Transport and storage is difficult. Transport and storage is difficult. Not suitable for overseas travel. Not suitable for overseas travel. Short shelf life (few organisms remain alive in solution after several weeks) Short shelf life (few organisms remain alive in solution after several weeks) Friendly bacteria damaged by pasteurization Friendly bacteria damaged by pasteurization (exposure to high temperatures 60 to 80 deg. C) (exposure to high temperatures 60 to 80 deg. C) Severe bacterial cell damage occurs if centrifugation and chemicals are used. Severe bacterial cell damage occurs if centrifugation and chemicals are used. Additives and preservatives are added to stabilize the bacteria in solution. Additives and preservatives are added to stabilize the bacteria in solution. Transport and storage is difficult. Transport and storage is difficult. Not suitable for overseas travel. Not suitable for overseas travel.

13. FERMENTED PASTE CONTAINING FRIENDLY BACTERIA The preparation of OM-X involves the use of natural organic ingredients and a natural non-chemical fermentation process unlike any other preparation process currently used by industry. - Bacteria-functional and viable. - Bacteria-functional and viable. - No damage to bacterial cell wall. - No damage to bacterial cell wall. - No centrifugation. - No centrifugation. - No freezing. - No freezing. - Storage and transport is easy. - Storage and transport is easy. - No preservatives and additives. - No preservatives and additives. - Bacteria-functional and viable. - Bacteria-functional and viable. - No damage to bacterial cell wall. - No damage to bacterial cell wall. - No centrifugation. - No centrifugation. - No freezing. - No freezing. - Storage and transport is easy. - Storage and transport is easy. - No preservatives and additives. - No preservatives and additives.

14. If antibiotics were the Medicine in the 20 th century, Probiotics will be the Medicine in the 21 st century. “Don’t just save lives, restore good health…” “Let OHHIRA-OMX Probiotics be your partner in care…” be your partner in care…” If antibiotics were the Medicine in the 20th century, Probiotics will be the Medicine in the 21st century. “Don’t just save lives, restore good health…” “Let OHHIRA-OMX Probiotics be your partner in care…” Luisito L. Ruiz, M.D., FICS Medical Director Luisito L. Ruiz, M.D., FICS Medical Director

15. GENERICA PHARMACY