1. The Integumentary System Normal skin, Genetic Defects, and Scar Formation

2. Cross section through human skin Keratin Stratified squamous epithelium Dense irregular connective tissue

4. Cross section through human skin

5. Pacinian corpuscle (note the onion-like appearance)

7. Meissner corpuscles located in the dermis

8. Melanin producing melanocytes

9. Genetic Abnormalities Associated with Skin

10. Epidermolysis Bullosa Fragile Skin, Blistering do to a defect in the adhesion molecules that keep the simple squamous epithelium together

11. Ichthyosis – Scaly fish disorder Harlequin Type 1 ichthysos

12. Neurofibromatosis – defect on Chromosome 1. Autoosmal dominant disorder

13. Incontinentia Pigmenti X-linked disorder, often fatal in boys, causes hyperpigmentation of the skin, blistering, loss of motor function, delayed growth, mental impairment

14. Albinism – A autosomal recessive genetic disorder in which the individual produces no melanin. Albinism occurs in all species and races

15. Simplified cross section of a hair

16. Scar Formation

20. Normal healing, epithelial cells move to the areaLittle or no fibroblast activityNormal healing, epithelial cells move to the areaLittle or no fibroblast activity

21. Mild hypertrophic scarring

22. Mild keloid formation

23. Keloid formation

24. Cesarean section scars then and now

27. Ritual scarification of the skin for religious or cultural reasons

28. Scarification as body art / modification

29. Diabetic ulceration of the foot, note the extensor tendons of the foot