1. Paul Whiteside, M.S., C.E.O. Email: whitesidephd@gmail.com Alt.: barmanne@gmail.com

2. Systematic Problems  “Point-and-shoot” paradigm  Easy to misuse  Inefficient procedures  No training required NPO’s:  64% of litigations ‘04-’12  100% of litigations in 2012  Mean indemnity payment is $380k 1,2

3. Waveguides:  Light transmitted directly into skin  No reflections  Easier to use  Anticipated to be more effective  Modular Stakeholder opinions:  Need to prevent accidental firing  Ergonomics are important  Efficiency is key

4. Market dynamics:  Total U.S. Market: $800M  $46M for consumables alone  CAGR: 12% (Frost & Sullivan)  R&D performed by Start-Ups Annual procedures: (clinics only)  33,363 tattoo removals  1,080,082 hair removal procedures  439,493 skin resurfacings Medical Spas make up another 30-60% of the market 3

5. Medical Photonics Industries:  Keurig-style business model  “Cheap” hand-pieces  Frequently purchased consumables  FDA 510(k)  Acquisition or partnership Market Leaders:  Syneron Medical: 14 acq, 7 pt, 2 lic  Cynosure: 4 acq, 4 dist  Palomar: 9 pt, 3 lic  Lumenis

6. Intellectual Property:  Patent pending through OTMIR (#13UMC079prov)  Additional patent disclosures filed FDA 510(k):  Show functional similarity to FDA approved laser devices  Hoya ConBio RevLite (K) 103118  SideLaze800 Laser Beam Accessory (K) 121127

7. Paul Whiteside Medical Photonics CEO M.S., Ph.D. Student Principal Inventor Eric Barmann Medical Photonics CFO B.S., M.B.A. I.P. expert John Viator, Ph.D. Advisory Board Program Director Biomedical Engineering Duquesne University Nicholas Golda, M.D. Advisory Board Medical Director Dermatology and Skin Surgery Center, University of Missouri Michael Flagg, PMP Advisory Board FDA Regulatory Expert, MU Research Reactor

8. 2014Q2 2015Q3 2015Q4 2015Q1 2016Q2 201620172018 Fast Track Funding (MU system grant) Efficiency Improvement (I.P. #2) Efficiency Improvement (I.P. #2) Preclinical Trials SBIR Application Waveguide Fabrication Optimization In vitro Pig Skin Testing In vitro Pig Skin Testing Prototype Fabrication Expected SBIR Decision Expected SBIR Decision Clinical Trials to follow in SBIR Phase II Coulter Seed Funding: Low-energy waveguide development Coulter Seed FundingSBIR Phase I, Phase II, Coulter, MTC

9. Paul Whiteside, M.S., C.E.O. Email: whitesidephd@gmail.com Alt.: barmanne@gmail.com

10. Image 1: www.thetattooeditor.com/laser-tattoo-removal-technique/ Image 2: www.deccanchronicle.com/140702/nation-current-affairs/article/most-indian-laser-clinics-do-not- follow-any-norms 1. H. Ray Jalian, “Increased Risk of Litigation Associated with Laser Surgery by Nonphysician Operators”, JAMA Dermatol. 150(4), 2014 2. H. Ray Jalian, “Common Causes of Injury and Legal Action in Laser Surgery”, JAMA Dermatol., 149(2), 2013 3. Cosmetic Surgery National Data Bank, Statistics 2014 www.surgery.org/sites/default/files/2014-Stats.pdf