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Transforming the CTRI and UCSD: From Silo to Collaboration Gary S. Firestein, M.D.

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Presentation on theme: "Transforming the CTRI and UCSD: From Silo to Collaboration Gary S. Firestein, M.D."— Presentation transcript:

1 Transforming the CTRI and UCSD: From Silo to Collaboration Gary S. Firestein, M.D.

2 Clinical and Translational Research Institute Organized Research Unit, est. 2010 Funded by institutional funds, CTSA, CTSA supplements, UCOP, industry funding and NHLBI U54 ~$59 M extramural funding Informatics, clinical research and laboaratory infrastructure Pilot project and Catalyst grants KL2/TL1/CREST programs co-funding of investigator initiated projects (30-60%) ~$50 M in grants requiring CTRI letter of support 782 members 655 UCSD SDSU, Sanford Burnham, Salk, LIAI, Venter, others

3 2010201120122013 Nurses/Coord Clinical Cores --DEXA --Exercise Clinical Cores --DEXA --Exercise Clinical Cores --DEXA --Exercise --Skin biopsy Clinical Cores --DEXA --Exercise --Skin biopsy --Cardiac phenotype Biostatistics IRB service Clinic Space (ECOB) Clinic Space (ECOB) Phase I unit Center for Clinical Research 2010-2013

4 Clinical and Translational Research Institute Clinical services since 2011 261 protocols in CCR ( 108 currently active) ~3000 visits/year 93 infusions (56 in first half of 2013) 220 skin biopsies 45 IRB submission consultations

5 New CTRI to break down silos Phase I unit Collaboration with the Cancer Center Standard of Care billing Experimental Pharmacy Overnight stays Begin in ECOB, then move to ACTRI

6 2010201120122013 Biomarker Biorepository --Storage Biorepository --Storage --Collection --Velos Biorepository --Storage --Collection --Velos --Management Affiliated Cores --Mass Spec Affiliated Cores --Mass Spec --HT screening Affiliated Cores --Mass Spec --HT Screening --Genomics Launching Pad Translational Research Technology 2010-2013

7 2010201120122013 CDWR CRIQueT REDCap ReX Biocomp Center --Genomics Biocomp Center --Genomics --Epigenomics --Systems Biology VelosEnterprise Velos Data Concierge Biomedical Informatics 2010-2013

8 Clinical and Translational Research Institute Informatics and Biomarker services since 2011 485 protocols in Velos (252 active) 62 Bioinformatics projects 99 Biomarker projects 19,027 biosamples processed or collected 18,392 biomarker assays performed

9 New CTRI to break down silos Genomics and bioinformatics Consolidate individual efforts at various centers in the Institute for Genomic Medicine Re-engineer BIOGEM Center for Bioinformatics Analysis Integrated assistance with study design, data analysis, systems biology, ‘omics data Collaboration and service models

10 CTRI Funding Education CTRI TL1 Program 3 m or 1 yr training for medical and pharmacy students CTRI KL2 Program Institutional K award $100 K/yr 10 Scholars funded since 2010 ~80 participants CTRI CREST Program Modular program that can lead to MAS Co-funding by the CTRI to lower tuition >100 participants

11 Simplifying access: ctri.ucsd.edu

12 2010201120122013 Translational Clinical Innovation Catalyst --CTRI services Catalyst --CTRI services Catalyst --CTRI services --Biomarkers --Drug discovery Personalized Medicine Engineering in Medicine Co-funding with other centers Pilot project grant program 2010-2013

13 Resources available at the CTRI: Catalyst grants

14 New CTRI to break down silos Drug Discovery at Sanford-Burnham High throughput screening Catalyst grants

15 Resources available at the CTRI: Pilot project grants

16 CTRI Funding Innovation Bringing engineers and clinicians together to apply technology to unmet medical needs GEM Program: Galvanizing Engineering in Medicine

17 Altman CTRI Building: Designed to break down silos


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