1. Beginning of the chapter Heart health and genetics (Cardiovascular Sensor) 39

2. SENSORS CARDIOVASCULAR SENSOR Cholesterol/Triglycerides Homocysteine Arteriosclerosis Sudden cardiac arrest

3. SENSORS CARDIOVASCULAR SENSOR Predisposition to: 1)High LDL cholesterol 2)Low HDL cholesterol 1)Effect of omega-3 on HDL cholesterol 3)High triglycerides 4)High homocysteine 1)Vitamin B2 positively effects the homocysteine levels 5)Prolongation of the QT intervals 6)Effect of 26 drugs

4. 22 genetic variations CARDIOVASCULAR DISEASES

5. Gene examples

6. CARDIOVASCULAR DISEASES Gene examples

7. CARDIOVASCULAR DISEASES Gene examples

8. CARDIOVASCULAR DISEASES Gene examples

9. CARDIOVASCULAR DISEASES Gene examples

10. CARDIOVASCULAR DISEASES Gene examples

11. CARDIOVASCULAR DISEASES Gene examples

12. CARDIOVASCULAR DISEASES Genetic predisposition

13. SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment

14. CARDIOVASCULAR DISEASES Counselling example Prevention Regular exercises Do not smoke! As little alcohol as possible Low-fat diet Less animal, more plant foods Use vegetable oils Omega3 fish oil capsules have a negative impact on your cholesterol Early detection Regular medical blood tests Submit to a Resting ECG examination before taking QT altering medication

15. CARDIOVASCULAR DISEASES High risk, what to do now? Early detection Regular medical blood tests Regular QT interval tests Measure the electrolyte level when performing extreme sports

16. SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment

17. PHARMACOGENETICS Various drugs and enzymes DRUG D 3A42C192E9 3A5 NAT2 DRUG C 2D6 DRUG B 2C9 DRUG A 1A2 break down

18. CARDIOVASCULAR DISEASES Optimal medication

19. CARDIOVASCULAR DISEASES Optimal medication

20. SENSORS CARDIOVASCULAR SENSOR Cardiovascular disease 1) Prevention 2) Early detection 3) Better treatment

21. End of the chapter Heart health and genetics (Cardiovascular Sensor) 39