2. Large glands of digestive system Pancreas

3. Function of liver : 1. Syntesis: Bile Plasma proteine Plasma lypoproteines (vitamine K, D, E, A, cholesterine) 2. Detoxication 3. Destruction of spent red cell and reclamation of their constituens 4. Universal haemopoetic organ 5. Endocrine - somatomedine

4. LIVER & Pancreas LIVER Bile Hepatic artery Portal vein GI worm Hepatic veins

5. Liver vasculature

6. Liver lobule

7. Liver specimen

8. Liver specimens

9. HEPATIC PARENCHYMA epithelial working tissue Plate of hepatocytes SINUSOID Plate of hepatocytes Endothelial cells Space Disse SINUSOID Kupffer cell blood PIT cell Itto cell (stellate cell)

10. CELL TYPES & ARRANGEMENT OF LIVER Microvilli Hepatocytes in plates Bile canaliculus SPACE OF DISSE Fenestrated Endothelial cells SINUSOIDKupffer cell STELLATE CELL HEPATOCYTE ENDOTHELIAL CELL KUPFFER CELL STELLLATE CELL

11. Hepatocyte, blood capilaries, bile canaliculus

12. Hepatocyte electron microhpoto

13. bile canaliculus electron microhpoto

14. Hepatocyte, blood capilaries, bile canaliculus

15. Schema of clasiccal and portal lobules and liver acinus

16. gallbladder

17. Epithelium of gallbladder

18. pancreas

19. Acinus and duct of pancreas

20. Homogenic and zymogenic zones

21. pancreatocyte

22. Langerhans islets

23. Classification of insulocytes: Cells%hormonfuncion В70-75 insulin insulin Lowers blood glucose, activates the formation of glycogen in the cells А20-25glucagon Increases blood glucose by glycogen clutch D5-10 VIP (vasoactive intestinal pep- tide), gastrin Reduces BP and simulates juice and hormone secretion D1-D1-D1-D1-1-2somatostatin Delays secretion of insulin and glucagon РР, F 2-5 pancreatic polypeptide Inhibits secretion of pacreatic juice

24. В and А cells inside Langerhan’s Islands

25. Insulocytes and fenestrated blood capillaries

26. Salivary glands Parotide, Submundibular, Sublingual+ numerous minor FUNCTIONS І. Exocrine 1. Food moistening 2. Desinfection 3. Digestion 4. Articulation ІІ. Endocrine (parotin, insulin-like factor, epithelium growth factor, nerve growth factor, vaso-active intestinal polypeptide, glucagon, callicrein, renin...) ІІІ. Excretion ІV. Homeostatic Saliva 1.Water-99% 2.Mineral (Na, K, Cа, Fe …) 3. Organic (enzymes, mucous) Cells (leukocytes, epitheliocytes)

27. MFU– ACINUS secretory potion+ intrecallated duct+ striated duct

28. Parotid gland

29. Submandibular gland

30. submandibular

31. Sublingual gland