1. Non-invasive image-guided breast brachytherapy (NIIGBB) [Patient Data Registry Excerpts] David E. Wazer, MD Tufts University School of Medicine Brown University School of Medicine

2. A multi-institutional assessment of the feasibility, implementation, and early clinical results with noninvasive image-guided breast brachytherapy for tumor bed boost. Subarna Hamid 1,2, Kathy Rocchio 2, Douglas Arthur 3, Robyn Vera 3, Sandra Sha 4, Michele Jolly 4, Sean Cavanaugh 5, Eric Wooten 5, Rashmi Benda 6, Brad Greenfield 6, Bradley Prestidge 7, Scot Ackerman 8, Robert Kuske 9, Coral Quiet 9, Margie Snyder 9 and David Wazer 1,2. 1 Tufts Medical Center, Boston, MA. 2 Brown University, Rhode Island Hospital, Providence, RI. 3 Virginia Commonwealth University, Richmond, VA. 4 Central Florida Cancer Institute, Davenport, FL. 5 Atlanta Oncology Associates, Hawkinsville, GA. 6 Boca Raton Community Hospital, Boca Raton, FL. 7 Texas Cancer Clinic, San Antonio, TX. 8 First Coast Oncology, Jacksonville, FL. 9 Arizona Breast Cancer Specialists, Phoenix, AZ 101 patients; median follow-up = 9 months (3-17 mos)

3. SKIN TOXICITY Grade 0Grade 1Grade 2 Acute Skin (1-3 wks) 59387 Intermediate Skin (4-26 wks) 206618 Late-interm Skin (>26 wks) 87130

4. SUBCUTANEOUS TOXICITY Grade 0Grade 1Grade 2 Acute SubQ (1-3 wks) 84160 Intermediate SubQ (4-26 wks) 83170 Late-interm SubQ (>26 wks)87130

5. % Excellent% good % fair% poor Boost upfront4555 00 During WBRT7624 00 Preliminary cosmesis rating for ≤ 6month follow-up…

6. Preliminary comparison of patient discomfort and ≤ 6month FU cosmesis

7. Preliminary Results

8. Preliminary Conclusions These data indicate that NIIGBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIIGBB is associated with acceptably mild normal tissue toxicity and favorable early cosmetic results. The application of NIIGBB before completion of WBRT may be associated with better patient tolerance at the expense of slightly less favorable cosmetic outcome. These data indicate that NIIGBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIIGBB is associated with acceptably mild normal tissue toxicity and favorable early cosmetic results. The application of NIIGBB before completion of WBRT may be associated with better patient tolerance at the expense of slightly less favorable cosmetic outcome.

9. Thank you dwazer@tuftsmedicalcenter.org