1. Developmental & Genetic Diseases By Dr. Ghada Ahmed Lecturer of pathology Benha Faculty of Medicine

2.  Definition  Teratogenic factors: Ch emicals & drugs I onizing radiation I nfection to mother Ch romosomal/ genetic abnormalities

3.  Severe  Less severe  Later on life

4. 46, XX 46, XY

5. Permanent change in DNA sequence of certain gene Abnormal gene New properties

6.  Point mutation

7. Genetic diseases Genetic defects (Mendelian Disorders) Chromosomal Disorders Diseases with Multifactorial Inheritence

8. Genetic defects Autosomal linked DominanatRecessiveSex-linkedX-linked

13. Genetic diseases Genetic defects (Mendelian Disorders) Chromosomal Disorders Diseases with Multifactorial Inheritence

14. Chromosomal aberration Structural aberrations Deletion Translocation Inversion Numerical aberrations Increased number Decreased number

21.  Polygenetic diseases  Multi-factorial diseases