1. What is a mutation?

2. Genetic Disorders Make a list of all the genetic disorders you have heard of – do you know what causes them?

3. Huntington's disease Lesson Learning Outcomes: Increasing Difficulty List the symptoms of Huntington’s disease Interpret genetic diagrams and family trees to predict the likelihood of inheriting genetic disorders Consider the ethical implications of treatments for genetic disorders

4. Huntington’s Disease We are going to watch a video about Huntington’s disease While you are watching the video write down any symptoms of Huntington’s disease.

5. Value Line How guilty is Carol Carr? Innocent Guilty

6. Value Line How guilty is Carol Carr? Innocent Guilty

7. Pass the buck! Your table has been given a placemat. Read the question in the middle of the placemat. Each person should take a square and write in their square the answer to the question

8. Genetic Crosses t tt tT t

9. Sickle cell anaemia Sickle cell anaemia is a recessive genetic disorder. What are the chances the child of two heterozygous parents will have sickle cell anaemia?

10. Hypercholesterolemia Hypercholesterolemia is a dominant genetic disorder. A homozygous recessive woman and a heterozygous man are going to have children. They want to know what the chances of their child inheriting the condition are.

11. Achondroplasia Achondroplasia is a dominant genetic disorder. What are the chances of two heterozygous parents having a child who inherits the condition?

12. Genetic Cross snowballing Write a problem for someone else (they must have to solve it using a genetic cross diagram). Don’t forget to say which characteristic is dominant and which one is recessive

13. Huntington's disease Lesson Learning Outcomes: Increasing Difficulty List the symptoms of Huntington’s disease Interpret genetic diagrams and family trees to predict the likelihood of inheriting genetic disorders Consider the ethical implications of treatments for genetic disorders

14. In a family with a history of Huntington’s why might a child not be allowed the test to see if they have it UNTIL their parents have been tested?

15. Why might some people choose to have a test for Huntington’s? What could the ethical implications be after having this test?

16. Why might some people choose not to have a test for Huntington’s? What could the consequences of this be?

17. A pregnant woman with a family history of Huntington’s disease is going to get the foetus tested for the disease. What are some of the ethical implications of this?

18. Apart from a person’s family, who else might be interested in the results of a genetic test? What might they do with this information?

19. Some genetic tests can give a “false positive” what do you think this is and what could the implications of this be?

20. Some genetic tests can give a “false negative” what do you think this is and what could the implications of this be?