1. Duke Center for Systems Biology

2. Origins “A systems biologist views biological problems through the eyes of a systems engineer”

3. Timeline 2003 20082004200520062007 Biological Networks Group formed First NIH proposal submitted Named NIH National Center for Systems Biology First DCSB Systems Biology Symposium Regular meetings and mini- tutorials held Became IGSP Center for Systems Biology. Move to FFSC space First annual Retreat and SAB review

4. Core faculty Pankaj Agarwal (Computer Science) Q Philip Benfey (Biology) E Herbert Edelsbrunner (Computer Science) Q Steve Haase (Biology) E John Harer (Mathematics) Q Alex Hartemink (Computer Science) Q Paul Magwene (Biology) E/Q Dave McClay (Biology) E Sayan Mukherjee (Statistics) Q Uwe Ohler (IGSP/Bioinformatics) Q Dave Schaeffer (Mathematics) Q Josh Socolar (Physics) Q Mike West (Statistics) Q Greg Wray (Biology) E Lingchong You (Biomedical Engineering) E/Q

5. Greg Wray Mike West Philip Benfey Steve Haase Lingchong You Sayan Mukherjee Uwe Ohler Alex Hartemink Joshua Socolar Paul Magwene David Schaeffer Pankaj Agarwal David McClay John Harer Center for Systems Biology Herbert Edelsbrunner

6. Greg Wray Mike West Philip Benfey Steve Haase Lingchong You Sayan Mukherjee Uwe Ohler Alex Hartemink Joshua Socolar Paul Magwene David Schaeffer Pankaj Agarwal David McClay John Harer Herbert Edelsbrunner

7. Mathematics Medicine Computer Science Statistical Science Physics Greg Wray Mike West Philip Benfey Steve Haase Lingchong You Sayan Mukherjee Uwe Ohler Alex Hartemink Joshua Socolar Paul Magwene David Schaeffer Pankaj Agarwal David McClay John Harer Biology Herbert Edelsbrunner

8. Mathematics Medicine Computer Science Statistical Science Physics Greg Wray Mike West Philip Benfey Steve Haase Lingchong You Sayan Mukherjee Uwe Ohler Alex Hartemink Joshua Socolar Paul Magwene David Schaeffer Pankaj Agarwal David McClay John Harer Biology Computational Biology and Bioinformatics Herbert Edelsbrunner

9. CSB associated faculty Jungsang Kim (Electrical Engineering) Jack Keene (MGM) Blanche Capel (Cell Biology) Dewey McCafferty (Chemistry)

10. Activities CSB meetings Education Outreach Faculty recruitment Research

11. Regular CSB activities Weekly meetings –“No stupid questions” rule Weekly lunches –Post-docs and grad students Journal club

12. Educational activities Grew out of internal mutual education activities –Quantitative reasoning for biologists –Biological processes for quantitative scientists

13. Undergraduate HHMI grant –$2 million Courses –Modeling Certificate –Structure/Function –Introductory Biology –Intro to Systems Biology

14. Mentored research Vertically Integrated Partner (VIP) teams –2 faculty, 2 grad students, 2 undergraduates –Summer research –Independent study

15. Graduate Integration into existing programs –CBB –UPGG –Developmental Biology –Cell and Molecular Biology

16. Graduate courses Modeling and engineering gene circuits –Lingchong You Computational biology of gene regulation –Uwe Ohler Computational systems biology –Alex Hartemink

17. Outreach Annual Systems Biology Symposia Workshops Postdoctoral Fellows program Sabbatical visitors

18. Partnership with NCCU Course: “Complex traits and systems biology” Summer Research Internships

19. Worldwide Network of Systems Biology Centers Bridging the quantitative/experimental divide Systems biology curriculum development Establishing, maintaining and sharing systems biology databases

20. Faculty recruitment Cluster hire –Interdisciplinary –Cross-school

21. Recruitment Over 150 applicants Interviewed 10 Two offers made –Biology - accepted –Physics – declined

22. Research projects Network dynamics

23. Time scales Cell cycle –Minutes to hours Development –Hours to months Evolution –Millions of years