1. Coenzymes Chapter 25

2. Coenzymes – Ch 25 1. What role do cofactors play? – Give an example of 2 types of cofactors

3. Coenzymes – Ch 25 2. Niacin is required to make the coenzymes ___(a)___, ___(b)___, ___(c)___ and ___(d)___ which are necessary for ___(e)___ reactions on functional groups that contain ___(f)___. The coenzymes ___(g)___ and ___(h)___ are used in catabolic pathways as opposed to the coenzymes ___(i)___ and ___(j)___ are used in anabolic pathways.

4. Coenzymes – Ch 25 3. Predict the products and provide the mechanisms for the following reactions: A.A. B.B.

5. Coenzymes – Ch 25 4. Vitamin B2 is required to make the coenzymes ___(a)___, ___(b)___, ___(c)___ and ___(d)___ which are necessary for ___(e)___ reactions in mostly compounds without the element ___(f)___.

6. Coenzymes – Ch 25 5. Predict the products and give the mechanism for A and B: A. B. C. D. Active site of FAD and FMN

7. Coenzymes – Ch 25 6. The conenzyme TPP is derived from the vitamin ___(a)___. TPP is required for ___(b)___ and ___(c)___ reactions on the substrate ___(d)___.

8. Coenzymes – Ch 25 7. Predict the products and provide the mechanism for the following:

9. Coenzymes – Ch 25 8. How many enzymes and coenzymes are involved in the pyruvate dehydrogenase system?

10. Coenzymes – Ch 25 9. The coenzyme biotin a.k.a. vitamin ___(a)___ is used for ___(b)___ reactions on ___(c)___ substrates. Biotin is accompanied by two other cofactors ___(d)___ and ___(e)___. Biotin is bound to it’s enzyme via a(n) ___(f)___ linkage to a ___(g)___ residue.

11. Coenzymes – Ch 25 10. Predict the product and provide the mechanism: