1. BURDEN OF INFLUENZA: MORTALITY AND DEATH

2. Everyone is at risk  100 million people infected every year in Northern Hemisphere* *In North America, Europe, and Japan. ESWI. Available at: http//www.eswi.org/library/bulletins/0499-4.html. CDC. MMWR. 2001;50(RR-04)1-46. 1:10 adults1:3 children10,000-40,000 deaths in the USA

3. 1. Vital and Health Statistics for CDC NCHS. Current estimates from the National Health Interview Survey, 1994. Series 10, No. 193. 2. Glezen WP, et al. J Infect Dis. 1987;155:1119-1126. The majority of people affected by influenza are adults, most of whom are “healthy” Influenza affects healthy adults Adults with influenza 1 –Rapid symptom onset –Confined to bed 3 to 7 days –Reduced activity 10 to 13 days Young adults with influenza 2 –Airway dysfunction/hyper- reactivity –May persist for weeks after infection

4. UK-based General Practice Research Database (GPRD). Meier CR, et al. Eur J Clin Microbiol Infect Dis. 2000;19:834-842. Most complications occur in healthy persons

5. 1. Meier CR, et al. Eur J Clin Microbiol Infect Dis. 2000;19:834-842. 2. Monto AS, et al. 9th International Congress on Infectious Diseases. April 2000; Buenos Aires, Argentina. Influenza- secondary complications Most complications affect otherwise healthy people 1 –Bronchitis, Pneumonia –Sinusitis –Exacerbation of comorbidity  60 - 80% of patients with secondary complications get antibiotics 1,2 Antibiotics are prescribed in  30 - 45% of patients with Influenza or ILI 1,2 Healthy Risk groups 62% 38%

6. Risk of influenza-associated deaths RiskRisk to die within one year due to 10 -2 - 10 -3 Smoking more than 10 cigarettes/Tag 10 -3 - 10 -4 Influenza Street accident 10 -4 - 10 -5 Leukemia Suicide 10 -5 - 10 -6 Train accident  10 -6 Lightning stroke Calman KC. BMJ. 1996;313:799-802.

7. By courtesy of Dr. T.D. Szucs, University of Zurich, Switzerland