1. Our students do well! Our programs are strong, particularly Postgraduate Residency and Clinical Fellowship We need to improve our Undergraduate Education performance Surgery University of Toronto Summary

2. Resident Presentation Nir Lipsman, R4 Neurosurgery 2nd year PhD student through IMS Supervisor: Dr Andres Lozano Surgeon Scientist Program Clinician Investigator Program CIHR Fellowship Resident Presentation Nir Lipsman, R4 Neurosurgery 2nd year PhD student through IMS Supervisor: Dr Andres Lozano Surgeon Scientist Program Clinician Investigator Program CIHR Fellowship Surgery University of Toronto

3. Probing and modulating neural circuitry underlying reward and emotional processing

4. Intraoperative single-unit recording (SUR) Post-operative multi-unit recording (MUR) Perioperative frequency analysis, interregional coherence and MUR

5. Intraoperative single-unit recording (SUR) Post-operative multi-unit recording (MUR) Perioperative frequency analysis, interregional coherence and MUR Deep Brain Stimulation Probing and modulating neural circuitry underlying reward and emotional processing

6. PhD SupervisorDr. Andres M. Lozano Collaborators University of Toronto: Dr. Jonathan Dostrovsky (Physiology) Dr. Bill Hutchison (Physiology) Dr. Peter Giacobbe (Psychiatry) Dr. Sidney Kennedy (Psychiatry) Dr. Blake Woodside (Psychiatry) Dr. Jeff Daskalakis (Psychiatry) Dr. Roger McIntyre (Psychiatry) Dr. Adam Anderson (Psychology) USC/McGill: Dr. Antoine Bechara (Neurology/Psychology) University of Hong Kong: Dr. Savio Wong (Psychology) University of Ottawa: Dr. Georg Northoff (Psychiatry/Psychology) Dr. Takashi Nakao (Psychology)

7. Probing and modulating neural circuitry underlying reward and emotional processing 1) Acquire unique data to answer questions not previously subject to empirical testing (e.g. The nature of self and its relationship to reward) 2) Develop novel therapeutic options for patients with no treatment alternatives (e.g. Treatment resistant psychiatric disease)

8. Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression DBS OwnFamousNeutral Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous vs. Neutral (p<0.05)

9. OwnFamousNeutral Mean firing rate for Own is significantly higher in first second of stimulus presentation vs. Famous vs. Neutral (p<0.05) Single-neuron activity during Self Task in Subgenual Cingulate Gyrus during Depression DBS

10. FAMOUS NEUTRA L OWN Logarithmic representation of local field potential frequencies Diminished power in alpha band ‘Frequency of Self’

11. Tasks now under development will look at decision-making under uncertainty, emotion recognition and reward anticipation From Neurophysiology to Clinical Research – Depression – Bipolar Disorder – Obsessive-Compulsive Disorder – Anorexia Nervosa – Schizophrenia – Drug Addiction – Alcoholism Disorders of self processing and primary reward dysfunction Implications

12. DepressionAlzheimer’s Disease DBS can modulate neural circuits underlying mood and memory Mayberg et al 2005; Laxton et al 2010

13. DisorderTargetSubjectsStatus *Obsessive- Compulsive Disorder Inferior Thalamic Peduncle 6 Operated on 1; Now recruiting *Bipolar Disorder type II Subgenual cingulate gyrus (SCG) 6 REB Approved; Now recruiting **Anorexia nervosa, restricting subtype SCG and Nucleus Accumbens (NAcc) 12 REB Approved; Now recruiting **Schizophrenia NAcc and Ventral Tegmental Area (VTA) 6 REB Approved; Now recruiting *Canadian First **Global First Modulating Neural Circuitry

14. Surgery University of Toronto Saturday July 9th, 2011 149 Mossgrove Trail Welcome Party for PGY1’s Saturday July 9th, 2011 149 Mossgrove Trail Welcome Party for PGY1’s

15. Surgery University of Toronto Coming your way in 2011- 12! Dept Webmaster Communications Stephanie Neilson Coming your way in 2011- 12!

16. Surgery University of Toronto Also Coming Your Way! Strategic Planning Initiative 2011-12 Also Coming Your Way!

17. Surgery University of Toronto Also Coming Your Way! Strategic Planning Initiative 2011-12 Co-Chairs Late fall, early winter Tagline: TBD Retreat: January 2012 Survey Monkey: Sept 2011 Stra: James Rutka and Bryce Taylor Facilitator: Helena Axler Timeline: tegic Foci: Education, Research, Faculty Development, Best Practices, Integration Also Coming Your Way!

18. Surgery University of Toronto A New Department of Surgery Brand! Keep your eyes open for..... SSP Logo New Dept Surgery Logo Keep your eyes open for.....

19. Surgery University of Toronto Thank you!