1. Advanced Brain-Wave Analysis For Early Diagnosis of Alzheimer’s Disease (AD) Jaron Murphy The Ohio State University Research Alliance in Math and Science Computational Sciences and Engineering, Oak Ridge National Laboratory Dr. Lee Hively & Dr. Nancy Munro http://www.ccs.ornl.gov/Internships/rams_08/j_murphy Abstract The goal of this study is improvement in distinguishing various disease states: normal aging, mild cognitive impairment, early Alzheimer’s disease(AD), and Diffuse Lewy Body disease(DLB). With the help of Dr. Robert Sneddon (University of California, Irvine), a Java program has been designed to model the Sneddon and Shankle qEEG methodology. The program analyzed data received from another collaborator, Dr. Yang Jiang (University of Kentucky School of Medicine), and calculated the ratio of variance of anterior cortical activity to the variance of posterior cortical activity. This measure will be used to identify the optimal cutoff value to discriminate normal from impaired subjects, and thus improve the accuracy for discriminating among disease states. Future Applications Anticipating a clinical device in the next several years that could be used by a physician to provide early diagnosis of AD in 5 to 10 years before AD onsetAnticipating a clinical device in the next several years that could be used by a physician to provide early diagnosis of AD in 5 to 10 years before AD onset Ability to provide early diagnosis of neurological diseases such as:Ability to provide early diagnosis of neurological diseases such as: Parkinson’s diseaseParkinson’s disease Diffuse Lewy Body diseaseDiffuse Lewy Body disease Clinical DepressionClinical Depression Bi-Polar DisorderBi-Polar Disorder The Research Alliance in Math and Science program is sponsored by the Office of Advanced Scientific Computing Research, U.S. Department of Energy. The work was performed at the Oak Ridge National Laboratory which is managed by UT-Battelle, LLC under Contract No. De-AC05-00OR22725. This work has been authored by a contractor of the U.S. Government, accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes. Background AD is a neurodegenerative disease of the nervous system that is:AD is a neurodegenerative disease of the nervous system that is: non-treatablenon-treatable affects the cognitive abilities of a personaffects the cognitive abilities of a person renders them functionally useless in societyrenders them functionally useless in society Federal government estimates approximately 4 million people in the U.S. has ADFederal government estimates approximately 4 million people in the U.S. has AD Number of people with AD will increase in future as number of older persons increasesNumber of people with AD will increase in future as number of older persons increases Advances in our understanding of AD, but no effective treatmentAdvances in our understanding of AD, but no effective treatment Effectiveness of treatments depend on implementing them at earliest stage of disease as possibleEffectiveness of treatments depend on implementing them at earliest stage of disease as possible Method Computational analysis of electroencephalography(EEG) data using the nonlinear Tsallis entropy, implemented in Java on desktop systemComputational analysis of electroencephalography (EEG) data using the nonlinear Tsallis entropy, implemented in Java on desktop system Analyzed EEG data collected at UK during administration of a delayed visual recall taskAnalyzed EEG data collected at UK during administration of a delayed visual recall task Fig. 1 Figure 2. Person wearing an electrocap that holds the electrodes in place Research Objectives Implement the qEEG Methodology in JavaImplement the qEEG Methodology in Java Analyze UK EEG data to see if Shankle and Sneddon’s results can be confirmedAnalyze UK EEG data to see if Shankle and Sneddon’s results can be confirmed Demonstrate early detection of DLB for the first time via qEEGDemonstrate early detection of DLB for the first time via qEEG Figure 3. Diagram of the four brain wave categories Fig. 3 Results Java code to calculate variance ratio Java code to calculate variance ratio Sample numerical results Sample numerical results Comparison across 40 data sets Comparison across 40 data sets Fig. 2 Fig. 1 Placement diagram of electrodes on the head Dsfjladfjladfj;dfdfdfsd Dsfjladfjladfj;dfdfdfsdlklkllklk