1. Chapter 7

2.  The nervous system allows the body to detect, interpret and respond to stimuli. ◦ A stimulus is any change in the external or internal environment.

3. Functions of the Nervous System 1. Sensory input  To monitor changes occurring inside and outside the body using sensory receptors 2. Integration  To process and interpret sensory input 3. Motor output  To produce a response, if needed, that activates muscles or glands (effectors)

5. Organization of the Nervous System Two main divisions: Central nervous system (CNS) Brain Spinal cord Peripheral nervous system (PNS) Nerves outside the brain and spinal cord

6. Organization of the Nervous System

7. Nervous tissue is made up of neuroglial (supporting ) cells and neurons. Neuroglial cells outnumber neurons. Neuroglial cells do not conduct impulses; neurons do. Neuroglial cells generally support, insulate and protect delicate neurons. Neuroglial cells are capable of dividing; neurons are not.

8. Supporting Cells

9. Neurons Neurons = nerve cells Specialized to transmit messages (impulses) Major regions of neurons: Cell body – nucleus and metabolic center of the cell Processes – fibers that extend from the cell body Dendrites – carry impulses towards the cell body Axon – carries impulse away from the cell body

10. Neurons

11. Neurons  Myelin sheath – fatty material surrounding axons produced by Schwann cells  Insulates axons  Speeds up transmission

12. Classification of Neurons  Sensory (afferent) neurons  Carry impulses from sensory receptors to the CNS  Motor (efferent) neurons  Carry impulses from the CNS to muscles or glands (effectors)  Interneurons (associative neurons)  Connect sensory and motor neurons

13. Classification of Neurons

14. The Nerve Impulse  The plasma membrane at rest is polarized (resting potential)  Fewer positive ions are inside the cell than outside the cell  Active transport by the sodium-potassium pump maintains this polarity

15. Starting the Nerve Impulse A stimulus depolarizes the neuron’s membrane Sodium ions (Na + ) rush inside the membrane This initiates an impulse (action potential) in the neuron

16. Continuing the Nerve Impulse  The impulse continues to move toward the cell body  Potassium ions rush out of the neuron which repolarizes the membrane  The sodium-potassium pump then establishes the original polarity

17. The Threshold  A minimum stimulus (threshold) is needed to start an impulse  If the threshold is met, a nerve impulse starts, and continues over the entire axon (all or none response)  Impulses travel faster when fibers have a myelin sheath

18. Neuron to Neuron Communication Neurons do not touch each other because of a gap called the synapse. Impulses cross the synapse with the help of chemicals called neurotransmitters. Neurotransmitters released from the axon terminal diffuse across the synapse The dendrite of the next neuron has receptors that are stimulated by the neurotransmitter An action potential (impulse) is started

19. Neuron to Neuron Communication

20. The Central Nervous System  Brain and spinal cord

21. Regions of the Brain  Cerebral hemispheres  Diencephalon  Brain stem  Cerebellum

22.  Cerebrum ◦ Voluntary activities (motor initiation), intelligence, learning, judgment, sensory interpretation ◦ Two hemispheres connected by the corpus callosum  Right hemisphere controls the left side of the body and visa-versa ◦ Deep folds and grooves increase surface area  Gray matter – outer layer of dense nerve cell bodies  White matter – inner layer of myelinated nerve fibers

23. Lobes of the Cerebrum  Fissures (deep grooves) divide the cerebrum into lobes  Surface lobes of the cerebrum  Frontal lobe  Parietal lobe  Occipital lobe  Temporal lobe

24. Specialized Areas of the Cerebrum  Primary sensory area (postcentral gyrus)– receives impulses from the body’s sensory receptors  Primary motor area (precentral gyrus)– sends impulses to skeletal muscles

25. Sensory and Motor Areas of the Cerebral Cortex

26. Specialized Area of the Cerebrum  Cerebral areas involved in special senses  Broca’s area – speech  Gustatory area - taste  Visual area - sight  Auditory area - hearing  Olfactory area – smell  Interpretation areas of the cerebrum  Speech/language region  Language comprehension region  General interpretation area

27. Specialized Area of the Cerebrum

28.  Two hemispheres with convoluted surfaces  Provides involuntary coordination of body movements  http://www.youtube.com/watch?feature=player_detailpage&v=F7Yw26zHoEw http://www.youtube.com/watch?feature=player_detailpage&v=F7Yw26zHoEw

29.  Sits on top of the brain stem  Enclosed by the cerebral hemispheres  Made of three parts  Thalamus – sensory relay station  Hypothalamus – controls hunger, thirst, fatigue, anger, temperature, coordinates with endocrine system  Epithalamus – pineal gland and choroid plexus (forms cerebrospinal fluid)

30. Attaches to the spinal cord Controls vital functions – blood pressure, heart rate, breathing, swallowing, vomiting Parts of the brain stem Midbrain Pons Medulla oblongata

31.  Scalp and skin  Skull and vertebral column  Meninges  Cerebrospinal fluid (CSF)  Blood-brain barrier

32. Figure 7.17a Superior sagittal sinus Subdural space Subarachnoid space Skin of scalp Periosteal Bone of skull Meningeal Dura mater Arachnoid mater Pia mater Arachnoid villus Blood vessel Falx cerebri (in longitudinal fissure only) Periosteum (a)

33. Figure 7.17b Skull Scalp Superior sagittal sinus Dura mater Transverse sinus Temporal bone Occipital lobe Tentorium cerebelli Arachnoid mater over medulla oblongata (b) Cerebellum

34. Cerebrospinal Fluid (CSF)  Similar to blood plasma composition  Formed by the choroid plexus ◦ Choroid plexuses–capillaries in the ventricles of the brain  Forms a watery cushion to protect the brain  Circulated in arachnoid space, ventricles, and central canal of the spinal cord

35. Figure 7.18a Septum pellucidum Inferior horn Lateral aperture Lateral ventricle Anterior horn Interventricular foramen Third ventricle Cerebral aqueduct Fourth ventricle Central canal (a) Anterior view

36. Figure 7.18b Lateral ventricle Anterior horn Interventricular foramen Third ventricle Cerebral aqueduct Fourth ventricle Central canal Posterior horn Inferior horn Median aperture Lateral aperture (b) Left lateral view

37. Blood-Brain Barrier  Includes the least permeable capillaries of the body  Excludes many potentially harmful substances  Useless as a barrier against some substances ◦ Fats and fat soluble molecules ◦ Respiratory gases ◦ Alcohol ◦ Nicotine ◦ Anesthesia

38. Traumatic Brain Injuries (TBI)  Concussion  Slight or mild brain injury  Bleeding & tearing of nerve fibers  Recovery likely with some memory loss  Contusion  A more severe TBI  Nervous tissue destruction occurs  Nervous tissue does not regenerate  Cerebral edema  Swelling from the inflammatory response  May compress and kill brain tissue

39. Cerebrovascular Accident (CVA)  Commonly called a stroke  The result of a ruptured blood vessel supplying a region of the brain  Brain tissue supplied with oxygen from that blood source dies  Loss of some functions or death may result

40. Alzheimer’s Disease  Progressive degenerative brain disease  Mostly seen in the elderly, but may begin in middle age  Structural changes in the brain include abnormal protein deposits and twisted fibers within neurons  Victims experience memory loss, irritability, confusion and ultimately, hallucinations and death

41. PNS: Cranial Nerves  Twelve pairs of nerves that mostly serve the head and neck  Only the pair of vagus nerves extend to thoracic and abdominal cavities  Most are mixed nerves, but three are sensory only

42. PNS: Cranial Nerves  I Olfactory nerve—sensory for smell  II Optic nerve—sensory for vision  III Oculomotor nerve—motor fibers to eye muscles  IV Trochlear—motor fiber to one eye muscle  V Trigeminal nerve—sensory for the face; motor fibers to chewing muscles  VI Abducens nerve—motor fibers to eye muscles  VII Facial nerve—sensory for taste; motor fibers to the face  VIII Vestibulocochlear nerve—sensory for balance and hearing  IX Glossopharyngeal nerve—sensory for taste; motor fibers to the pharynx  X Vagus nerves—sensory and motor fibers for pharynx, larynx, and viscera  XI Accessory nerve—motor fibers to neck and upper back  XII Hypoglossal nerve—motor fibers to tongue

43. Figure 7.24 I Olfactory II Optic III Oculomotor IV Trochlear VI Abducens V Trigeminal VII Facial Vestibular branch Cochlear branch VIII Vestibulocochlear X Vagus IX Glossopharyngeal XI Accessory XII Hypoglossal

44. PNS: Cranial Nerves Device  Oh – Olfactory  Oh – Optic  Oh – Oculomotor  To – Trochlear  Touch – Trigeminal  And – Abducens  Feel – Facial  Very – Vestibulocochlear  Green – Glossopharyngeal  Vegetables – Vagus  Ah – Accessory  Ha – Hypoglossal

45. Extension of brain stem Controls reflexes Surrounded by meninges (membranes) Central canal is filled with spinal fluid Protected by vertebrae. Gray matter – mostly cell bodies White matter – myelinated cell fibers

46. Spinal Cord  Extends from the medulla oblongata to the region of T12  Below T12 is the cauda equina (a collection of spinal nerves)  Enlargements occur in the cervical and lumbar regions

47. Spinal Cord  Central canal filled with cerebrospinal fluid

48. The Reflex Arc  Reflex – rapid, predictable, and involuntary responses to stimuli  Reflex arc – direct route from a sensory neuron, to a spinal cord interneuron, to an effector  No brain involvement

49. Peripheral Nervous System  Nerves and ganglia outside the central nervous system  A nerve consists of neuron fibers bundled by connective tissue  There are twelve pairs of cranial nerves and 31 pairs of spinal nerves.  Somatic nerves control voluntary functions and autonomic nerves control involuntary functions

50. A nerve has layers of connective tissue. The endoneurium is a delicate connective tissue wrapping around each fiber. The perineurium is a coarser wrapping around a bundle of fibers (fascicle). The epineuriun is a tough connective tissue wrapping around all the fascicles. Nerves may contain just sensory neurons, just motor neurons, or both (mixed).

51. PNS: Spinal Nerves  There is a pair of spinal nerves at the level of each vertebrae.  Formed by the combination of the ventral and dorsal roots of the spinal cord  Named for the region from which they arise

52. PNS: Spinal Nerve Plexuses  Plexus–networks of nerves serving motor and sensory needs of the limbs  Form from ventral rami of spinal nerves in the cervical, lumbar, and sacral regions  Four plexuses: ◦ Cervical ◦ Brachial ◦ Lumbar ◦ Sacral

53. Cervical nerves Thoracic nerves Lumbar nerves Sacral nerves Ventral rami form cervical plexus (C 1 – C 5 ) Ventral rami form brachial plexus (C 5 – C 8 ; T 1 ) No plexus formed (intercostal nerves) (T 1 – T 12 ) Ventral rami form lumbar plexus (L 1 – L 4 ) Ventral rami form sacral plexus (L 4 – L 5 ; S 1 – S 4 ) (a) C1C1 T1T1 L1L1 2 3 4 5 6 7 8 2 3 4 5 6 7 8 9 10 11 12 2 3 4 5 S1S1 2 3 4 Figure 7.25a

54. PNS: Autonomic Nervous System  Motor subdivision of the PNS ◦ Consists only of motor nerves  Also known as the involuntary nervous system ◦ Regulates activities of cardiac and smooth muscles and glands  Two subdivisions ◦ Sympathetic division ◦ Parasympathetic division

55. PNS: Autonomic Functioning  Sympathetic—“fight or flight” ◦ Response to unusual stimulus ◦ Takes over to increase activities ◦ Remember as the “E” division  Exercise, excitement, emergency, and embarrassment  Parasympathetic—“housekeeping” activites ◦ Conserves energy ◦ Maintains daily necessary body functions ◦ Remember as the “D” division  digestion, defecation, and diuresis

56. Anatomy of the Autonomic Nervous System

57. Comparison of Somatic and Autonomic Nervous Systems