1. Company LOGO Longer Life, Better Life Presenter: 陈昊 Representing The third group ——Current research progress on Alzheimer Disease

2. Company name 21 st century--time for the aged Number of the aged is so huge! October 31st, 2011 7 billion people on the world? 0.7 billion is the old! Almost 1 in 10 on the world is over 60!

3. Company name Aging is everywhere! Number of the aged (current and predicted) of some continents 4-5 times increasing in 50 years, just like a rocket! What about China? The pace is faster.

4. Company name The Result of aging: Enjoy a longer life Life expectancy worldwide on 2007 From Wikipedia CIA World Fact book 2007 : Over 100 nations or regions enjoy the life expectancy over 70! Quality of life?

5. Company name Living quality---A better life as well? Economic influence Social problems Health and diseases Aging is good or not? This is a question. The tragedy of aging:

6. Company name The position of Alzheimer diabetes CHF Stroke Neurodegenerative disease hypertension Aged diseases When we become old…… Cancer Alzheimer

7. Company name Contents 1 The characters of Alzheimer2 Alzheimer----the killer of life quality3 Research on Mechanism of Alzheimer4 Current drug and therapy5 Can Alzheimer be prevented? Fight against Alzheimer!

8. Company name 1 Alzheimer--- four stages characters EarlyMiddle Severe Final 1. slow, progressive loss of intellectual ability 2.difficulty learning 3.mild depression 1.an increase in memory loss 2.Decrease losing of daily living ability 1.unable to recognize objects and family members 1.cannot speak or walk, even breathe 2.has profound memory loss Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30

9. Company name Epidemiology: the high rate of AD in the aged The percentage of AD (%) The older one is, the more risky on getting AD!

10. Company name 2. Alzheimer destroys the quality of life Danger of the patients Remember loss Ability loss cognition loss 15-20 years!

11. Company name Alzheimer destroys the quality of life Social problems TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661 Have you remembere d or not? ! Mercy killing! Living without quality or die at once, this is a question!

12. Company name 3.The mechanism of Alzheimer—so many hypothesis Cholinergic hypothesis The mechanism Of Alzheimer Amyloid hypothesis Acetylcholine (ACh) production elimination imbalance 11C-PIB PET images characteristic Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011) Rubbish in brain!

13. Company name New research: The interaction between these hypothesis MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111 Amyloid hypothesis to Cholinergic one: The more rubbish, the less Ach is!

14. Company name New research: The interaction between these hypothesis MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111 Cholinergic hypothesis to Amyloid one: Ach inhibits the rubbish’s producing! amyloid

15. Company name 4.Current Drug and therapy Current Drug for AD H3 antagonist 5-HT receptor ACEIs New ACEIs Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age- related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210 Donepezil Rivastigmine Galantamine …… Huperzine A Mianserin 5-HT 2A antagonist Effect in cognition loss 2004 Ciproxifan 2009 Thioperamide 2006 Anti-depressant only?

16. Company name A large market in AD drug and therapy Drugs for AD have a large market.

17. Company name The mechanism of ACEIs The Cholinergic pass way decompose Ach Re-uptake X AChE: Acetylcholinesterase

18. Company name 5. Can Alzheimer be prevented? Emotional Therapy? anti-amyloid Therapy? Diet Therapy? Chinese Traditional medicine? Virus-like Vaccine? Prevention Of AD Biotech therapy Self therapy

19. Company name Current research: Biotech vaccine Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11 Virus-like particle based vaccines for AD 2010 Virus-like particle based antigen High-affinity antibody anti- amyloid! currently in human clinical trials virus

20. Company name ---Live longer, live better! Conclusion Our love To the old? Better prevention More drugs Mechanism clearer live longer, live better. It’s not only for the old, but also for our future!

21. Company name Reference and acknowledgements 1 Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30 2 TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660- 1661 3 Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137– 152 (2011) 4 MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111 5 Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210 6 Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11

22. Company LOGO We not only focus on study progress, but also the research areas around the world! Honor product of F0917101 TM Scientific 药院出品，必属佳作