1. Founders With the support of

2. 2 Letters of intent  Individual quotation, then selection by the SAB Validation by the Bureau  Full Application  Individual quotation, then selection by the SAB Proposal to the bureau  Selection and validation by Executive Comittee Selection process 40 15 10

3. 3 Selected Projects Comparison of bioassay, Scrapie Cell- Assay and Protein Misfolding Cycle Assay performances for detection of endogenous Prion in sheep blood Principal Investigator: O. Andreoletti (INRA-ENVT, Toulouse, France)

4. 4 Selected Projects Probing the chemistry and conformational change underlying autocatalytic self- propagation of misfolded prion protein Principal Investigator: M. Beekes (Robert Koch Institute, Berlin, Germany)

5. 5 Selected Projects Optimisation, evaluation and validation of a PMCA-based confirmatory screening assay to detect prions in human blood. A French and British Collaborative Study Principal Investigators: J. Coste (EFS-PM, Montpellier, France) M. Jones (SNBTS, Edinburgh, UK)

6. 6 Selected Projects Assessment of prion infectivity in blood in primate and sheep models, and evaluation of removal processes (extension 2009) Principal Investigator: D. Dernis (EFS-Nord, Lille, France)

7. 7 Selected Projects Infectivity titrations of blood components from chimpanzees infected with the agent of Gerstmann-Sträussler-Scheinker Syndrome in mice and comparison of sensitivity of mouse bioassays Principal Investigator: L. Gregori (FDA, USA)

8. 8 Selected Projects Evaluation of cold atmospheric plasma to decontaminate surgical instrument surfaces and eliminate prion infectivity Principal Investigators: C. W. Keevil (Southampton University, UK) R. Hervé (Southampton University, UK)

9. 9 Selected Projects An assessment of the relevancy of sheep and mice animal model for blood safety investigation Principal Investigator: C. Lacroux (INRA-ENVT, Toulouse, France)

10. 10 Selected Projects Detection of PrPSc (a biomarker for TSE infection) in blood using QUIC shake technology: validation of in vitro studies with infectivity models Principal Investigators: J. C. Manson (The Roslin Institute, UK) S. MacCutcheon (The Roslin Institute, UK)

11. 11 Selected Projects Elucidation of the misfolding process… Insights into a preamyloid state by selectively trapping prion proteins in oligomeric forms Principal Investigator: J. Torrent (INSERM, Montpellier, France)

12. 12 Selected Projects Risk assessment of Insoluble PrP from normal human brains Principal Investigator: W.Q. Zou (Case Western Reserve University, Cleveland, USA)