1. Chapter 1 Introduction

2. Branches of Genetics 4. Quantitative genetics 1. Transmission genetics
Classical or Mendelian genetics
2. Molecular genetics
chromosomes, DNA, regulation of gene expression
recombinant DNA, biotechnology, bioinformatics, genomics, proteomics
Population, evolutionary genetics
allelic frequencies in populations
effects of migration
study relatedness of taxa via DNA and protein analysis
4. Quantitative genetics
effects of many genes

3. What is a gene? A unit of inheritance
A specific location on a chromosome
A sequence of base pairs
Transcribed into mRNA
Encodes a protein
Expressed
The specifier of a phenotype
Composed of DNA

4. Model Organisms
cheap to grow short generation time can control mating no ethical concerns many offspring some have simpler systems small (most)

5. Why use model organisms?
Development
Disease
Metabolic pathways (biochemistry)
Evolution
All living organisms share a common descent

6. Prokaryotic model organism
Bacteria E. coli

7. Eukaryotic model organism
1. Unicellular
Saccharomyces cerevisiae
Bakers yeast
Chlamydomonas reinhardtii
Green algae

8. 2. Multicellular Neurospora crassa C. elegans Orange bread mold
Nematode worm
1mm long, 959 cells, transparent

9. transparent development
Xenopus laevis
big eggs
Zebra danio
transparent development .

10. Arabidopsis thaliana
small plant/mustard family
Drosophila melanogaster
Fruit fly
Mus musculus