1. Synaptic Transmission

2. Electrical & Chemical Synapses Electrical & Chemical Synapses

3. Events Involved in Transmission at a Chemical Synapse

4. Local Recycling of Synaptic Vesicles in Presynaptic Terminals

5. Presynaptic Proteins Implicated in Neurotransmitter Release

6. Molecular Mechanisms of Neurotransmitter Release

8. Diseases that Affect the Presynaptic Terminal Lambert-Eaton myasthenic syndrome = Ab mediated Several congenital forms result in fewer or smaller vesicles = less transmitter

9. Toxins That Affect Transmitter Release Toxins cleave SNAREs Tetanus affects inhibitory interneurons = hyperexcitation of muscles Botulism paralyzes peripheral muscles = do not contract

10. Toxins That Affect Transmitter Release Black widow venom = exocytosis w/o calcium Binds to CL1 and neurexin, neurexin binds to synaptotagmin

11. Diseases Caused by Altered Ion Channels FHM = familial hemiplegic migraine EA2 = episodic ataxia CSNB = congenital stationary night blindness