1. + Biochemical Compounds You are what you eat!!

2. Organic Chemistry ● Frederick Wohler founded organic chemistry in 1828. ● Organic chemistry is one of the fastest growing areas of chemistry. ● Organic chemistry gave the foundation of the petrochemical and pharmaceutical industry.

3. Our Focus ● Our focus will be on the major classes of organic compounds: o Carbohydrates o Lipids o Proteins o Nucleic acids

4. 1. What are the 4 main types of biological macromolecules and what is their function within cells? 2. How does the structure of each macromolecule contribute to their function within cells? 3. What are the 4 major types of biochemical reactions and why are they important to normal cellular function? Essential Questions:

5. Carbon: The Central Atom What’s so special about? The diversity of life relies on carbon!!! Virtually all chemicals of life are carbon based (exceptions – e.g., H 2 O, CO 2 ) – called organic compounds. It can form four covalent bonds (H, O, N, P, S, C) C-C bonds enable carbon to form a variety of geometrical structures (e.g., straight chains, branched chains, rings) Methane CH 4 Ethane C 2 H 6 Benzene C 6 H 6 + CH 2 + C 4

6. Review - Functional Groups ● Functional groups are the reactive portion of an organic molecule and typically make the molecule polar. ● Common functional groups found in biomolecules: o Hydroxyl (–OH) o Carboxyl (–COOH) o Amino (–NH 2 ) o Sulfhydryl (–SH) o Phosphate (–PO 4 ) o Carbonyl  Aldehydes (–COH)  Ketones (–CO–)

7. Let’s See What you Remember… Circle and name the functional groups in the following organic molecule.

8. Molecular Isomers: The same, yet different What’s so special about ? Isomer – an organic compound with the same molecular formula, but different structure Fructose (fruit sugar) Galactose (milk sugar) C 6 H 12 O 6 Glucose (simple sugar) Example: C C C C C C C C C Metabolized by cells differently due to structure Structural isomers

9. Molecular Isomers: The same, yet different What’s so special about ? Isomer – an organic compound with the same molecular formula, but different structure Structural isomers Same atoms, bonded differently Stereoisomers Same atoms, Same bonds, Differently arranged in space GeometricalOptical

10. Molecular Isomers: The same, yet different What’s so special about ? Isomer – an organic compound with the same molecular formula, but different structure Stereoisomers Same atoms, Same bonds, Differently arranged in space Geometrical Optical Carvone

11. Macromolecules What is the relationship between atoms, bonding and macromolecules? Atoms Bonds Molecules Macromolecules join together that form that form large structures called

12. Macromolecules and their subunits Monomer ++=Polymer=Macromolecule smaller subunits long chain of monomers glucose glycogen

13. Carbon Compounds include Which are made of which contain Which are made of which contain CarbohydratesLipids Nucleic acids (e.g., DNA/RNA) Proteins Simple sugars (e.g., glucose) Glycerol & 3 Fatty Acids Nucleotides Amino Acids Carbon, hydrogen, oxygen Carbon, hydrogen, oxygen Carbon, hydrogen oxygen, nitrogen, phosphorus Carbon, hydrogen, oxygen, nitrogen, Macromolecules and their subunits 1 2 3 4 ENERGY STORAGE short-term main function ENERGY STORAGE long-term CATALYSIS & STRUCTURE /SUPPORT ENCODING HEREDITARY INFORMATION

14. Carbon Compounds include Which are made of which contain Which are made of which contain CarbohydratesLipids Nucleic acids Proteins Simple sugars (e.g., glucose) Glycerol & 3 Fatty Acids Nucleotides Amino Acids Carbon, hydrogen, oxygen Carbon, hydrogen, oxygen Carbon, hydrogen oxygen, nitrogen, phosphorus Carbon, hydrogen, oxygen, nitrogen, Carbohydrates 1 2 3 4 Main Function: quick and short-term energy storage Groupings: C, H, and O atoms (1 : 2 : 1 ratio) Two types: 1. Simple Carbohydrates 2. Complex Carbohydrates ENERGY STORAGE short-term main function (4 cal/g)

15. Carbohydrate molecule with 3-7 carbon atoms is called a monosaccharide. (mono = one, saccharide = sugar) Broken down quickly in the body to release energy. e.g., GLUCOSE – hexose (six-carbon) sugar with 7 energy-storing C-H bonds Carbohydrates – Simple (glucose) C 6 H 12 O 6 (ring structure – when dissolved in water) 1 2 3 4 5 6 Primary source of energy used by all cells

16. MONOSACCHARIDES QUIZ: Select the formula that represents a monosaccharide C 4 H 8 O 4 C 5 H 10 O 10 C 6 H 6 O 12 C 6 H 6 O 6

17. Making & Breaking Carbohydrates Condensation (dehydration) synthesis Hydrolysis Two important biochemical reactions monosaccharide + disaccharide (di = two)

18. Carbohydrates – Complex (Polysaccharides) Starch Granules (purple) in Potato Cells Starch = energy storage in plants Main Function: quick and short-term energy storage Contain many units of glucose in long chains Examples: Starch, glycogen, cellulose

19. Glycogen = energy storage in animals Glycogen (red) in Hepatocytes (liver cells) Glucose (monomer) Glycogen (polymer) Carbohydrates – Complex (Polysaccharides) liver muscle

20. Carbohydrates – Complex (Polysaccharides) Cellulose = polysaccharide found in plant cell walls Cellulose fibers Macrofibril Microfibril Chains of cellulose

21. Carbohydrates – Complex (Polysaccharides) What is the difference between starch and cellulose? Starch Cellulose

22. Starch Cellulose Glucose repeat units are facing the same direction Each successive glucose unit is upside-down in relation to each of the glucose molecules that it is connected to Both polymers Same repeat base Same monomer (glucose) Stronger (good for building)Weaker Enzymes to digest Cannot digest (no enzymes) Insoluble (fiber / roughage) Soluble

23. Things to Think About ●Photosynthesis produces glucose in the plant cell ●Concentration of glucose increases, osmotic pressure increases, cell risks explosion ●Cell converts unused glucose to amylose (α helix) and amylopectin (branched α helix) collectively called starch (stored for later use) ●Starch is insoluble and reduces osmotic pressure ●Animals store glucose as glycogen (stored for later use) ●Plants use β glucose to produce cellulose (insoluble building material for the plant)