1. A Small Dose of ToxicologyWelcome to Large Dose of Toxicology Paracelsus Paracelsus was so grandiose And perhaps just a little bit gross Manure, blood, and sand and thus you create man But what makes it a poison is dose! The Undecided Dose Too much of a thing makes you blue But not having it can kill you too Too much or too little Let's not be so fickle We'll go Dutch and divide it by two. Limericks by Toni Hayes

2. A Small Dose of ToxicologyWelcome to Large Dose of Toxicology

3. A Small Dose of ToxicologyWelcome to Large Dose of Toxicology A Larger Dose of Toxicology Welcome !! Introduction to the Health Effects of Chemicals Steven G. Gilbert, PhD, DABT www.asmalldoseof.org www.toxipedia.org 2010 Northwest Hazardous Materials Management Conference June 10, 2010

4. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Objective Increase our understanding of how chemicals affect human health.

5. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology 8:00Overview to “A Larger Dose of Toxicology” 8:30Non-Cancer and Neurotoxicology 9:30Break 9:50 Case Study: Health Effects of Lead 11:00Precautionary Assessment – Beyond RA 11:45Questions and Answers 12:00Adjourn A Large Dose of Toxicology

6. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology A Small Dose of Toxicology See: www.asmalldoseof.org -- smdosesmdose

7. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Small Dose of Toxicology

8. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Milestones of Toxicology

9. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology www.toxipedia.org A free toxicology encyclopedia and resource center that anyone can edit. Toxipedia provides comprehensive, accurate, and scientifically based information on the hazards and risks of chemical and physical agents, with the goal of advancing human and environmental health. ToxipediaToxipedia

10. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology The World Library of Toxicology

11. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Toxipedia suite of sites www.ipmopedia.org www.healthyworldtheater.org www.wanmec.org www.toxipedia.org www.wltox.org

12. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology www.wltox.org

13. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Connecting Gardeners and Experts for Green Gardening Solutions  Identify Your Pest  Find the Right Plant  Ask the Experts  Garden Design Guide  Indoor Pest Control www.ipmopedia.org Supported by Local Hazardous Waste Management Program in King County, WA.

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15. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Healthy World Theater http://healthyworldtheater.org promote awareness and understanding through the arts to create a more healthy and peaceful world plays, poems, jokes, fiction, music, cartoons, haiku, and even limericks

16. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology 16

17. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Washington Nuclear Museum and Educational Center (WANMEC) http://wanmec.org learning from the past for a safer tomorrow a project of Washington Physicians for Social Responsibility - funded in part by WA DOE

18. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Toxipedia www.toxipedia.org Connecting Science and People Washington Nuclear Museum and Education Center - www.wanmec.org Integrate Pest Management www.IPMopedia.org World Library of Toxicology www.wltox.org Healthy World Theater www.healthyworldtheater.org A product of the Institute of Neurotoxicology and Neurological Disorders (INND) For more information contact Steven G. Gilbert at sgilbert@innd.org Connecting Gardeners and Experts for Green Gardening Solutions Learning from the past for a safer tomorrow Uniting art and science for a healthy, peaceful world Connecting Scientists and Experts to Improve Global Health

19. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Creating websites and communication tools for the scientific and nonprofit community Putting scientific information in the context of history, society, and culture Toxipedia Web Development Services

20. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology LDDI Consensus Statement Scientific Consensus Statement on Environmental Agents Associated with Neurodevelopmental Disorders Developed by the Collaborative on Health and the Environment’s Learning and Developmental Disabilities Initiative November 7, 2007 http://www.iceh.org/LDDI.html

21. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology LDDI Consensus Statement http://www.iceh.org/LDDI.html Given the established knowledge, protecting children from neurotoxic environmental exposures from the earliest stages of fetal development clearly is an essential public health measure if we are to help prevent learning and developmental disorders and create an environment in which children can reach and maintain their full potential.

22. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology NW Public Health See: http://healthlinks.washington.edu/nwcphp/nph/ nwph Public Health and the Precautionary Principle By Steven G. Gilbert

23. A Small Dose of ToxicologyWelcome to Large Dose of Toxicology Precautionary Principle “When an activity raises threats of harm to human health or the environment, precautionary measures should be take even if some cause and effect relationships are not fully established scientifically.” Wingspread Conference, 1998.

24. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Child Health

25. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology So Many Chemicals so Little Data 2863 above 1 Million pounds 78.2% no data 21.4% some data 12 or 0.4% good data www.preventingharm.org

26. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology  Nearly 12 million children (17%) under age 18 in the US suffer from one or more developmental disabilities  Learning disabilities – 5-10% of kids in public school  ADHD – 3-6% of all school kids, maybe higher The Consequences

27. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology Key Words of Toxicology Hazard X Exposure = Risk Individual Susceptibility Dose / Response

28. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology A Small Dose of – web site A Small Dose of Toxicology www.asmalldoseof.org

29. A Small Dose of ToxicologyWelcome to Small Dose of ToxicologyWelcome to Large Dose of Toxicology A Larger Dose of Toxicology