1. International perspectives on human gene editing: South Africa KEYMANTHRI MOODLEY DIRECTOR & PROFESSOR CENTRE FOR MEDICAL ETHICS & LAW DEPARTMENT OF MEDICINE FACULTY OF HEALTH SCIENCES STELLENBOSCH UNIVERSITY SOUTH AFRICA

2. South Africa Population +/- 52 million GDP $350 billion (US) 19.3%------9.1% on health-----1.3% (Pakistan) Clinical trials +/- 2500

3. GINI COEFFICIENT 0.77

4. HIV Burden of Disease 6.8 million HIV positive 340 000 new infections 200 000 deaths 42% on ARVs

6. Justice & Equity Research & Capacity Development Cost of treatment Access to gene editing?

7. Public Engagement Vulnerable populations Science translation Informed Consent

8. Academy of Science of South Africa National Health Act National Health Research Ethics Council