1. How Could Familial Genetic Testing Be More Effective in Early and Accurate Diagnosis of Idiopathic Hypertrophic Subaortic Stenosis as Compared to Traditional Echocardiogram Testing? By: Victoria Brooke Green April 3, 2009 East Tennessee State University Research In Allied Health – ALHE 4060-904 Professor: Dr. Randy Byington

2. IHSS is when the walls of the left ventricle of the heart becomes enlarged, obligating the heart to work harder to pump blood to the body. Traditionally, Idiopathic Hypertrophic Subaortic Stenosis (IHSS) has been diagnosed by having an echocardiogram following shortness of breath, chest pain, weakness, and exercise intolerance. It is crucial to determine if an individual has IHSS before the deadly side effects occur, and familial genetic testing is a way to accomplish this.

3. How does IHSS present itself in various age groups? Is IHSS gender and/or genetically predisposed? Can some individuals be carriers and pass the disease on to their biological children? How likely is this? How can exercise induce and aggravate symptoms in patients with IHSS? What reliable treatment opportunities exist for patients with IHSS?

4. IHSS is a lethal, quick-acting heart disease that strikes many people with little warning, if any. IHSS is acquired genetically and often misdiagnosed. The purpose of this study is to evaluate the possibility of advanced diagnosis using familial genetic testing. By interviewing IHSS patients and cardiologists about their opinions and knowledge concerning genetic testing, we can learn the best strategies in early diagnosing patients before fatal side effects may take them by surprise.