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THE IMMUNE SYSTEM LECTURER: DAVID
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ANTIGEN-ANTIBODY INTERACTIONS
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INNATE VERSUS ADAPTIVE RESPONSE INNATEADAPTIVE
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ANTIBODY!
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ANTIBODY STRUCTURE
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WHAT IS AN ANTIBODY??
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BUT WHAT IS AN ANTIGEN???
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SUMMARY
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ANTIBODY FUNCTIONS
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NEUTRALIZATION
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OPSONIZATION
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PHAGOCYTOSIS
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COMPLEMENT
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AGGLUTINATION
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ABO BLOOD GROUPS
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THERE ARE LOTS OF TYPES OF ANTIBODIES
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IgG
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IgA
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IgM
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IgE
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IgD
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OBJECTIVES
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QUESTION Which immunoglobulin can cross the placenta?
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ANSWER IgG
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QUESTION If you mix a person with type A blood and anti-A antibodies, will agglutination occur?
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ANSWER Yes
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QUESTION What is the difference between neutralization and opsonization?
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ANSWER Neutralization – antibody binds a toxin and makes it harmless Opsonization – antibody binds an antigen and targets it for phagocytosis
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