1. Essentials of Human Anatomy & Physiology Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slides 4.1 – 4.32 Seventh Edition Elaine N. Marieb Chapter 4 Skin and Body Membranes Lecture Slides in PowerPoint by Jerry L. Cook

2. Skin and Body Membranes Slide 4.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Function of body membranes  Line or cover body surfaces  Protect body surfaces  Lubricate body surfaces

3. Classification of Body Membranes Slide 4.2 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Epithelial membranes  Cutaneous membrane  Mucous membrane  Serous membrane  Connective tissue membranes

4. Cutaneous Membrane Slide 4.3 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Cutaneous membrane = skin  A dry membrane  Outermost protective boundary  Superficial epidermis  Keratinized stratified squamous epithelium  Underlying dermis  Mostly dense connective tissue Figure 4.1a

5. Mucous Membranes Slide 4.4 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Surface epithelium  Type depends on site  Underlying loose connective tissue (lamina propria)  Lines all body cavities that open to the exterior body surface  Often adapted for absorption or secretion Figure 4.1b

6. Serous Membranes Slide 4.5 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Surface simple squamous epithelium  Underlying areolar connective tissue  Lines open body cavities that are closed to the exterior of the body  Serous layers separated by serous fluid Figure 4.1c

7. Serous Membranes Slide 4.6 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Specific serous membranes  Peritoneum  Abdominal cavity  Pleura  Around the lungs  Pericardium  Around the heart Figure 4.1d

8. Connective Tissue Membrane Slide 4.7 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Synovial membrane  Connective tissue only  Lines fibrous capsules surrounding joints Figure 4.2

9. Integumentary System Slide 4.8 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Skin (cutaneous membrane)  Skin derivatives  Sweat glands  Oil glands  Hairs  Nails

10. Skin Functions Slide 4.9a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Protects deeper tissues from:  Mechanical damage  Chemical damage  Bacterial damage  Thermal damage  Ultraviolet radiation  Desiccation

11. Skin Functions Slide 4.9b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Aids in heat regulation  Aids in excretion of urea and uric acid  Synthesizes vitamin D

12. Skin Structure Slide 4.10a  Epidermis – outer layer  Stratified squamous epithelium  Often keratinized (hardened by keratin)

13. Layer of Epidermis Slide 4.11a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Stratum basale  Cells undergoing mitosis  Lies next to dermis  Stratum spinosum  Stratum granulosum

14. Layer of Epidermis Slide 4.11b  Stratum lucidum  Occurs only in thick skin  Stratum corneum  Shingle-like dead cells

15. Melanin Slide 4.12 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Pigment (melanin) produced by melanocytes  Color is yellow to brown to black  Melanocytes are mostly in the stratum basale  Amount of melanin produced depends upon genetic and exposure to sunlight

16. Skin Color Determinants Slide 4.14  Melanin  Yellow, brown or black pigments  Carotene  Orange-yellow pigment from some vegetables  Hemoglobin  Red coloring from blood cells in dermis capillaries  Oxygen content determines the extent of red coloring  Cyanosis - Low oxygen content creates a bluish appearance

17. MELANIN How Sun Effects Melanin

18.  Dermis  Dense connective tissue

19. Dermis Slide 4.13a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Two layers  Papillary layer  Projections called dermal papillae  Pain receptors  Capillary loops  Reticular layer  Blood vessels  Glands  Nerve receptors

20. FINGERPRINTS WHIRL ARCH LOOP Arise from the interaction of an individual’s genes and the developmental environment in the uterus. Genes determine general characteristics of patterns that are used for fingerprint classification. As the skin on the fingertip differentiates, it expresses these general characteristics. This skin is also in contact with the amniotic fluid in the uterus and other parts of the fetus and the uterus, and their position in relation to uterus and the fetal body changes as the fetus moves on its own and in response to positional changes of the mother. The area around growing cells on the fingertip is in flux, and is always slightly different from hand to hand and finger to finger. Their effect is amplified by the differentiating cells and produces the larger differences that enable the fingerprints of even identical twins to be differentiated.

21. Skin Structure Slide 4.10b  Deep to dermis is the hypodermis  Not part of the skin  Anchors skin to underlying organs  Composed mostly of adipose tissue

22. Skin Structure Slide 4.13b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 4.4

23. Appendages of the Skin Slide 4.15  Sebaceous glands  Produce oil  Lubricant for skin  Kills bacteria  Most with ducts that empty into hair follicles  Glands are activated at puberty

24. Appendages of the Skin Slide 4.16 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Sweat glands  Widely distributed in skin  Two types  Eccrine  Apocrine

25.  Eccrine sweat gland  Open via duct to pore on skin surface

26.  Apocrine sweat gland  Ducts empty into hair follicles

27. Sweat and Its Function Slide 4.17 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Composition  Mostly water  Some metabolic waste  Fatty acids and proteins (apocrine only)  Function  Helps dissipate excess heat  Excretes waste products  Acidic nature inhibits bacteria growth  Odor is from associated bacteria

28. Appendages of the Skin Slide 4.18 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Hair  Produced by hair bulb  Consists of hard keratinized epithelial cells  Melanocytes provide pigment for hair color Figure 4.7c

29. HAIR FOLLICLE

30. Hair Anatomy Slide 4.19 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Central medulla  Cortex surrounds medulla  Cuticle on outside of cortex  Most heavily keratinized Figure 4.7b

31. Asian, Caucasian, African In this cross-section of a hair root, the dark cortex and medulla are surrounded by the interlocked cuticles, Huxley's and Henle's layers, the outer epithelial root sheath, a deeply stained basement membrane and, finally, the well- vascularized connective tissue sheath.

32. Associated Hair Structures Slide 4.20 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Hair follicle  Dermal and epidermal sheath surround hair root  Arrector pilli  Smooth muscle  Sebaceous gland  Sweat gland Figure 4.7a

33. Appendages of the Skin Slide 4.21 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Nails  Scale-like modifications of the epidermis  Heavily keratinized  Stratum basale extends beneath the nail bed  Responsible for growth  Lack of pigment makes them colorless

34. Nail Structures Slide 4.22 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Free edge  Body  Root of nail  Eponychium – proximal nail fold that projects onto the nail body Figure 4.9

35. Skin Homeostatic Imbalances Slide 4.23 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Infections  Athletes foot  Caused by fungal infection  Boils and carbuncles  Caused by bacterial infection  Cold sores  Caused by virus

36. Skin Homeostatic Imbalances Slide 4.24 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Infections and allergies  Contact dermatitis  Exposures cause allergic reaction  Impetigo  Caused by bacterial infection  Psoriasis  Cause is unknown  Triggered by trauma, infection, stress

37. Skin Homeostatic Imbalances Slide 4.25 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Burns  Tissue damage and cell death caused by heat, electricity, UV radiation, or chemicals  Associated dangers  Dehydration  Electrolyte imbalance  Circulatory shock

38. Rules of Nines Slide 4.26 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Way to determine the extent of burns  Body is divided into 11 areas for quick estimation  Each area represents about 9%

39. Severity of Burns  First-degree burns  Only epidermis is damaged  Skin is red and swollen  Second degree burns  Epidermis and upper dermis are damaged  Skin is red with blisters  Third-degree burns  Destroys entire skin layer  Burn is gray-white or black

40. Critical Burns Slide 4.28 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Burns are considered critical if:  Over 25% of body has second degree burns  Over 10% of the body has third degree burns  There are third degree burns of the face, hands, or feet

41. Skin Cancer Slide 4.29 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Cancer – abnormal cell mass  Two types  Benign  Does not spread (encapsulated)  Malignant  Metastasized (moves) to other parts of the body  Skin cancer is the most common type of cancer

42. Skin Cancer Types Slide 4.30 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Basal cell carcinoma  Least malignant  Most common type  Arises from statum basale  Squamous cell carcinoma  Arises from stratum spinosum  Metastasizes to lymph nodes  Early removal allows a good chance of cure

43. Skin Cancer Types  Malignant melanoma  Most deadly of skin cancers  Cancer of melanocytes  Metastasizes rapidly to lymph and blood vessels  Detection uses ABCD rule

44. ABCD Rule Slide 4.32 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  A = Asymmetry  Two sides of pigmented mole do not match  B = Border irregularity  Borders of mole are not smooth  C = Color  Different colors in pigmented area  D = Diameter  Spot is larger then 6 mm in diameter

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