1. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport on behalf of the Hungarian Pancreatic Study Group 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups PINEAPPLE Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport Analyses of Pediatric Pancreatitis APPLE Andrea Párniczky BUDAPEST, HUNGARY Analyses of Pediatric Pancreatitis APPLE

2. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport CHILDREN 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

3. 1.The protocols have been discussed in our latest international meeting held in Szeged in November 2014, where expert pediatric pancreatologists attended. ( http://pancreas.hu/sites/info/files/conferences/ALPD2014-Program.pdf ) http://pancreas.hu/sites/info/files/conferences/ALPD2014-Program.pdf 2.The studies have received the relevant ethical approval (No. ad.52499-3/2014) issued by the National Hungarian Ethical Authority (ETT TUKEB). 3.The trial has been registered at the ISRCTN registry (ISRCTN89664974) which is a primary clinical trial registry recognized by WHO and ICMJE.ISRCTN89664974 4.The study is open for all pediatric centers throughout the world. 5.Electronic CRF has been developed. 6.The IAP Scientific Committee has approved the study and advertised worldwide among its 4000 members (16.06.2015) 7.The TRIAL article (prestudy protocol) is accepted, will be published in Digestion 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

4. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport Number of centres: 12 PINEAPPLE APPLE SZEGED BUDAPEST NYÍREGYHÁZA DEBRECEN PÉCS SZEKSZÁRD ZALAEGERSZEG SZÉKESFEHÉRVÁR BALASSAGYARMAT 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

5. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport APPLE Understand our EARLIER PRACTICE in pediatric pancreatitis Specify the GENETIC BACKGROUND of pediatric pancreatitis APPLE-R Understand the FAMILY HISTORY in pediatric pancreatitis Patients with HISTORY of pancreatitis under 18 ys 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

6. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport APPLE APPLE-R Acute Pancreatitis (AP) Acute Recurrent Pancreaitis (ARP) Chronic Pancreatitis (CP) Autoimmune Pancreatitis (AIP) Pancreatic Cancer (PC) + Other diseases Details from the medical history Etiology Genetic Test if available 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

7. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport APPLE 2 TUBES (EDTA) OF BLOOD SHIP TO SZEGED Storage - 20 C FOR GENETIC ANALYSES 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups APPLE Analyses of Pediatric Pancreatitis It has to be cost effective We can offer an unbeatable cost effective way for you: WE WILL DO IT FOR FREE!

8. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport GET MORE DETAILS and RECOGNIZE BETTER the course of the pediatric pancreatitis Specify the GENETIC BACKGROUND of pediatric pancreatitis Identify EARLY RISK FACTORS (etc: smoking-first, second-hand) Establishment of the SEVERITY at admission APPLE-P NEWLY diagnosed patient under 18 ys with pancreatitis (PINEAPPLE CAN HELP) APPLE 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

9. Admission details, status Laboratory parameters at admission Amylase (U/l) Lipase (U/l) (only obligatory if amylase is not measured) White blood cell (WBC) count (G/l) Red blood cell (RBC) count (T/l) Hemoglobin (g/l) Hematocrit (%) Thrombocyte (G/l) Serum glucose (mmol/l) Blood urea nitrogen (mmol/l) Creatinine (umol/l) eGFR C-reactive protein (mg/l) ASAT/GOT (U/l) Lactate dehydrogenase LDH (U/l) Calcium (mmol/l) OBLIGATORY Imaging at admission Details from the medical history Abdominal US Chest CT Chest X-ray Abdominal CT Abdominal X-ray AT ADMISSION! Immediate therapy at admission Complications Complains, symptoms 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport APPLE Analyses of Pediatric Pancreatitis

10. APPLE FOR EVERY DAY! Every day of the hospitalization the “APPLE-P FORM-B Questionnaire daily” needs to be filled out. General medical treatment 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport APPLE Analyses of Pediatric Pancreatitis

11. Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport Thank you for joining to us! We are waiting for more centres! 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE

12. THE HUNGARIAN PANCREATIC STUDY GROUP IS COMMITTED TO IMPROVING THE LIVE OF PATIENTS SUFFERING FROM PANCREATIC DISEASES! www.pancreas.hu Hungarian Pancreatic Study Group – Magyar Hasnyálmirigy Munkacsoport 4 th Conference of the Hungarian & 2 nd Conference of the Eastern and Central European Pancreatic Study Groups Analyses of Pediatric Pancreatitis APPLE