1. Principles of Oncology Professor Ravi Kant

2. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor Boveri-1914 chromosomal abnormalities Watson & Crick-1953- DNA

3. Apoptosis

4. Cancer cells → Undemocratic Autonomous Avoid Apoptosis Neoangiogenesis Invasion Proliferation

5. Cancer cellls Genomic instability

6. Malignant transformation

7. Gompertzian curve

9. Kaplan-Meier Kaplan-Meier Curve

10. Clinical implication of Gompertzian curve

11. Genetic Cancer Breast Thyroid

12. Prevention of Cancer Diet Life style

13. Early detection of cancer Screening- for cancer of Oral: Intraoral examination Breast: Mammography Stomach: Upper GI endoscopy Prostate: PSA level in serum

14. Diagnosis & Staging

16. Rx of Cancer Surgery Radiotherapy Chemotherapy Isotope Therapy Immunotherapy Immuno-modulation Receptor blockade of cancer

17. Team Multidisciplinary approach

20. Rx of T= Tumour N= Node M= Metastasis

21. Palliation

22. End of life care ? Nobel prize

23. Quality of life Dignity

24. Thanks