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Published byBerniece Burke Modified over 9 years ago
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CYSTIC FIBROSIS AND CELL COMMUNICATION
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CFTR Cystic Fibrosis Transmembrane Conductance Regulator ( Or CFTR) Is a transport protein for Chloride across cell membranes. Helps in the production of mucus, urine, and other waste products Allows free flow of water and Cl - ions throughout the cell.
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CYSTIC FIBROSIS AND DISRUPTION OF CFTR Cause: Cystic Fibrosis is caused by a mutation of CTFR, most commonly a deletion of three nucleotides. CF is an autosomal recessive disease Salt and water are no longer able to move in and out of the cell freely, as they were prior to this mutation.
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SYMPTOMS Symptoms of CF include: Sinus Problems/Frequent Infections Frequent Lung Infections Abnormal Pancreas Function Can Lead To Diabetes Difficulty Digesting Food Poor Growth and Nutrition Causes Infertility
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TREATMENTS Pulmonary Rehab Usually Steroids are administered to stimulate cell activity Synthetic Protein Channels Complete Lung Replacement As cells continue to deteriorate, a total lung transplant becomes required Insulin injections and pumps are frequently used to treat the symptom of diabetes.
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SYMPTOMS CONT. Deterioration of cells usually lead to shorter lifespan in people with CF People with CF, on average, develop diabetes at a much earlier age than people without.
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GENETICS CF is a recessive gene disorder Most commonly caused by a loss of the amino acid phenylalanine Most people have to copies of the CFTR protein, two mutated copies are needed to cause Cystic Fibrosis.
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CONCLUSION Add your conclusion here
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QUESTIONS & DISCUSSION
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